Analysis of Ebola virus Zaire 2014 isolates

A. Yu. Popova; V. A. Ternovoy; O. V. P’Yankov; E. V. Chausov; Ar. A. Sergeev; A. S. Kabanov; S. A. Bodnev; R. B. Bayandin; V. M. Blinov; N. F. Magassouba; V. V. Kutyrev; Yu. V. Demina; E. B. Ezhlova; A. P. Agafonov; V. N. Mikheev

doi:10.21055/0370-1069-2015-3-83-88

Проблемы особо опасных инфекций (Sep 2015)

Analysis of Ebola virus Zaire 2014 isolates

A. Yu. Popova,
V. A. Ternovoy,
O. V. P’Yankov,
E. V. Chausov,
Ar. A. Sergeev,
A. S. Kabanov,
S. A. Bodnev,
R. B. Bayandin,
V. M. Blinov,
N. F. Magassouba,
V. V. Kutyrev,
Yu. V. Demina,
E. B. Ezhlova,
A. P. Agafonov,
V. N. Mikheev

Affiliations

A. Yu. Popova: Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare; Russian Medical Academy for Post-Graduate Training
V. A. Ternovoy: State Research Centre of Virology and Biotechnology “Vector”
O. V. P’Yankov: State Research Centre of Virology and Biotechnology “Vector”
E. V. Chausov: State Research Centre of Virology and Biotechnology “Vector”
Ar. A. Sergeev: State Research Centre of Virology and Biotechnology “Vector”
A. S. Kabanov: State Research Centre of Virology and Biotechnology “Vector”
S. A. Bodnev: State Research Centre of Virology and Biotechnology “Vector”
R. B. Bayandin: State Research Centre of Virology and Biotechnology “Vector”
V. M. Blinov: State Research Centre of Virology and Biotechnology “Vector”
N. F. Magassouba: Donka National Hospital
V. V. Kutyrev: Russian Research Anti-Plague Institute “Microbe”
Yu. V. Demina: Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare
E. B. Ezhlova: Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare
A. P. Agafonov: State Research Centre of Virology and Biotechnology “Vector”
V. N. Mikheev: State Research Centre of Virology and Biotechnology “Vector”

DOI: https://doi.org/10.21055/0370-1069-2015-3-83-88
Journal volume & issue: Vol. 0, no. 3
pp. 83 – 88

Abstract

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Analysis of 5 Ebola virus Zaire 2014 isolates passaged in cell cultures or in mice, demonstrated presence of unique mutations in the genome RNA in some cases. All identified nucleotide substitutions are singular, stochastically located, synonymous or fall within non-coding regions. Variability level of nucleotide sequences is equal to 0.005-0.01 %, suggesting extremely high genetic stability of Ebola virus Zaire, the causative agent of the outbreak. Confirmed is suppression of non-synonymous mutations accumulation in ebolavirus variants in the course of time. Detected are alterations in glycosilation sites and mucin-like domain of ebolavirus glycoprotein.

Published in Проблемы особо опасных инфекций

ISSN: 0370-1069 (Print); 2658-719X (Online)
Publisher: Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”
Country of publisher: Russian Federation
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: https://journal.microbe.ru

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Abstract

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