Clinical and economic efficiency of multi-matrix mesalazine in ulcerative colitis treatment in the healthcare system of the Republic of Kazakhstan

Abstract

Aim: Clinical and economic evaluation of multi-matrix mesalazine 1200 mg compared with prolonged-release mesalazine at a dose of 500mg for the treatment of patients aged 18 years and older with the diagnosis of ulcerative colitis in the phase of exacerbation and remission. Material and methods: In accordance with the PICOS tool all published literature sources were identified in the electronic resources PubMed/Medline, DARE, Cochrane Central Register of Controlled Trials; the analysis included 5 studies with levels of evidence A and B. Calculations were performed in STATA and Microsoft Excel 10.0 Results and discussion: According to the results of clinical and economic analysis, the strategy of using multi-matrix mesalazine is dominant in comparison with prolonged-release mesalazine as a first-line therapy and contributes to the increment of efficiency and leads to the minimization of costs to achieve a QALY unit per patient. Patients receiving multi-matrix mesalazine have a longer duration of remission and less likelihood of re-exacerbations. Conclusion: The use of multi-matrix mesalazine in comparison with prolonged-release mesalazine is an economically feasible alternative in the conditions of health care of the Republic of Kazakhstan – more effective and less financially costly, leading to potential budget savings.

Keywords

• multi-matrix mesalazine
• non-specific ulcerative colitis
• Crohn's disease
• efficacy
• QALY