Medičnì Perspektivi (Mar 2013)
Impact of proteolysis processes on development and progressing of cardiac insufficiency of is chemic genesis depending on revascularisation
Abstract
Investigation and comparative assessment of the activity of matrix metalloproteinases MMP-9 and MMP-2 in 187 patients with chronic ischemic heart disease and all forms of acute coronary syndrome mean age 62 ± 1,5 years in applying the standard basic therapy, thrombolytic and antithrombin therapy was carried out. It was established, that in patients with acute co¬ronary syndrome and chronic ischemic heart disease; diverse changes in activity of the processes of proteolysis are observed, the presence of heart failure leads to a comparative increase in the activity of MMP-2 and MMP-9 in patients with acute coronary syndrome, but a greater effect on these processes causes the time of the beginning of treatment and receiving thrombolytic therapy; significant increasing activity of both matrix metal-proteinases is associated with the long process of formation and progression of heart failure, with the development of severe chronic heart failure, a gradual decrease in activity of matrix metal-proteinases.
