Nature Communications (Dec 2018)
Molecular and functional heterogeneity of IL-10-producing CD4 + T cells
- Leonie Brockmann,
- Shiwa Soukou,
- Babett Steglich,
- Paulo Czarnewski,
- Lilan Zhao,
- Sandra Wende,
- Tanja Bedke,
- Can Ergen,
- Carolin Manthey,
- Theodora Agalioti,
- Maria Geffken,
- Oliver Seiz,
- Sara M. Parigi,
- Chiara Sorini,
- Jens Geginat,
- Keishi Fujio,
- Thomas Jacobs,
- Thomas Roesch,
- Jacob R. Izbicki,
- Ansgar W. Lohse,
- Richard A. Flavell,
- Christian Krebs,
- Jan-Ake Gustafsson,
- Per Antonson,
- Maria Grazia Roncarolo,
- Eduardo J. Villablanca,
- Nicola Gagliani,
- Samuel Huber
Affiliations
- Leonie Brockmann
- I. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Shiwa Soukou
- I. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Babett Steglich
- I. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Paulo Czarnewski
- Immunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institute and University Hospital
- Lilan Zhao
- Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf
- Sandra Wende
- I. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Tanja Bedke
- I. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Can Ergen
- I. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Carolin Manthey
- I. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Theodora Agalioti
- Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf
- Maria Geffken
- Institute of Transfusion Medicine, University Medical Center Hamburg-Eppendorf
- Oliver Seiz
- I. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Sara M. Parigi
- Immunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institute and University Hospital
- Chiara Sorini
- Immunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institute and University Hospital
- Jens Geginat
- INGM-National Institute of Molecular Genetics “Romeo ed Enrica Invernizzi”
- Keishi Fujio
- Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo
- Thomas Jacobs
- Department of Immunology, Bernhard-Nocht-Institute of Tropical Medicine
- Thomas Roesch
- Department for Interdisciplinary Endoscopy, University Medical Center Hamburg-Eppendorf
- Jacob R. Izbicki
- Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf
- Ansgar W. Lohse
- I. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Richard A. Flavell
- Department of Immunobiology, School of Medicine, Yale University
- Christian Krebs
- III. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Jan-Ake Gustafsson
- Department of Biosciences and Nutrition, Karolinska Institutet
- Per Antonson
- Department of Biosciences and Nutrition, Karolinska Institutet
- Maria Grazia Roncarolo
- Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, ISCBRM, Stanford School of Medicine
- Eduardo J. Villablanca
- Immunology and Allergy Unit, Department of Medicine, Solna, Karolinska Institute and University Hospital
- Nicola Gagliani
- I. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Samuel Huber
- I. Department of Medicine, University Medical Center Hamburg-Eppendorf
- DOI
- https://doi.org/10.1038/s41467-018-07581-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Tr1 cells are considered an immunosuppressive CD4 T cell population producing IL-10. Here the authors show that IL-10 is insufficient for Tr1 immunosuppression, define surface markers and transcriptional program of the immunosuppressive subset within Tr1, and reveal its deficiency in patients with IBD.
