Interactions between Obstructive Sleep Apnea Syndrome Severity, Obesity, Sex Difference and Attention-Deficit/Hyperactivity Disorder on Health-Related Quality of Life: A Non-Interventional Prospective Observational Study
Yu-Hsuan Chen,
Ming-Feng Wu,
Chih-Yu Wen,
Shih-Pei Chang,
Ching-Yi Lin,
Yi-Chan Chen,
Ching-Cheng Lin,
Hui-Chen Chen,
Wei-Chang Huang,
Kai-Ming Chang
Affiliations
Yu-Hsuan Chen
Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung 406, Taiwan
Ming-Feng Wu
Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung 406, Taiwan
Chih-Yu Wen
Department of Electrical Engineering, National Chung Hsing University, Taichung 402, Taiwan
Shih-Pei Chang
Department of Physical Education, Central Taiwan University of Science and Technology, Taichung 406, Taiwan
Ching-Yi Lin
Department of Internal Medicine, Division of Chest Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan
Yi-Chan Chen
Department of Internal Medicine, Division of Chest Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan
Ching-Cheng Lin
Department of Internal Medicine, Division of Chest Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan
Hui-Chen Chen
Department of Internal Medicine, Division of Chest Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan
Wei-Chang Huang
Department of Internal Medicine, Division of Chest Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan
Kai-Ming Chang
Department of Internal Medicine, Division of Chest Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan
Obstructive sleep apnea syndrome (OSAS) severity, obesity, sex difference, and attention-deficit/hyperactivity disorder (ADHD) had a complex impact on health-related quality of life (HRQoL). However, the interactive effects among these features on HRQoL remained to be clarified. This study aimed to investigate the individual and interactive associations between the four characteristics of interest and HRQoL as determined by 36-Item Short Form Health Survey, Pittsburgh Sleep Quality Index (PSQI), and Epworth Sleepiness Scale (ESS). This non-interventional, prospective, observational study enrolled a total of 132 patients with suspected OSAS for analysis. While OSAS severity and ADHD detected by adult ADHD Self-Report Scale, termed as screened ADHD, interact with each other, all the four studied features were individually associated with HRQoL. After adjusting for potential physiological and polysomnographic confounders, screened ADHD was independently correlated with PSQI > 5 (OR = 4.126, 95% CI, 1.490–11.424), mental component score 10 (OR = 3.648, 95% CI, 1.738–7.657). Our results show that ADHD detection is necessary and should be incorporated into clinical practice for OSAS management.
