Онкогематология (Nov 2022)

Myeloid/natural killer cell precursor acute leukaemia. Case report and literature review

  • V. R. Gorodetsky,
  • N. A. Probatova,
  • N. N. Tupitsyn,
  • A. M. Kovrigina,
  • E. N. Sholokhova,
  • M. A. Frenkel,
  • T. T. Kondratyeva,
  • L. Yu. Grivtsova,
  • E. V. Fleishman,
  • A. I. Pavlovskaya

DOI
https://doi.org/10.17650/1818-8346-2007-0-3-65-69
Journal volume & issue
Vol. 0, no. 3
pp. 65 – 69

Abstract

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We describe a rare case of myeloid/NK cell precursor acute leukemia (MNKL) in a 38-year-old woman. Upon diagnostic examination, a tumor invasion of bone marrow, lymphatic nodes, liver and spleen was found. The proportion of blasts in peripheral blood reached 54%. The blasts were polymorphic, with round or irregularly shaped nuclei. The tumor cells were negative for myeloperoxidase, non-specific esterase, and lipid staining. The blasts not only expressed CD13+ and CD33+ panmyeloid antigens, but also carried the markers of NK-cell differentiation (CD16+, CD56+, Perforin+). The leukemoid infiltration of liver, acute hepatitis and development of liver cell failure were the distinctive features of the described case. The issues pertaining to differential diagnostics and classification of MNKL are also discussed.

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