The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis

Motohiro Sekiya; Kenta Kainoh; Takehito Sugasawa; Ryunosuke Yoshino; Takatsugu Hirokawa; Hiroaki Tokiwa; Shogo Nakano; Satoru Nagatoishi; Kouhei Tsumoto; Yoshinori Takeuchi; Takafumi Miyamoto; Takashi Matsuzaka; Hitoshi Shimano

doi:10.1038/s41467-021-26638-5

Nature Communications (Nov 2021)

The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis

Motohiro Sekiya,
Kenta Kainoh,
Takehito Sugasawa,
Ryunosuke Yoshino,
Takatsugu Hirokawa,
Hiroaki Tokiwa,
Shogo Nakano,
Satoru Nagatoishi,
Kouhei Tsumoto,
Yoshinori Takeuchi,
Takafumi Miyamoto,
Takashi Matsuzaka,
Hitoshi Shimano

Affiliations

Motohiro Sekiya: Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba
Kenta Kainoh: Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba
Takehito Sugasawa: Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba
Ryunosuke Yoshino: Transborder Medical Research Center, University of Tsukuba
Takatsugu Hirokawa: Transborder Medical Research Center, University of Tsukuba
Hiroaki Tokiwa: Department of Chemistry, Rikkyo University, Nishi-Ikebukuro
Shogo Nakano: Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka
Satoru Nagatoishi: The Institute of Medical Science, The University of Tokyo
Kouhei Tsumoto: The Institute of Medical Science, The University of Tokyo
Yoshinori Takeuchi: Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba
Takafumi Miyamoto: Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba
Takashi Matsuzaka: Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba
Hitoshi Shimano: Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba

DOI: https://doi.org/10.1038/s41467-021-26638-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 19

Abstract

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Sensing of nutrient status coordinates the regulation of liver glucose and lipid metabolism, and is important for metabolic homeostasis. Here the authors report that transcriptional the corepressor CtBP2 can sense nutrient status and coordinate repression of liver glucose and lipid metabolism via Fox01 and SREBP1, respectively.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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