We investigate two physical systems within a spacetime region affected by the nontrivial topology. The set-up for our analysis is a Minkowski metric perturbed by elements reflecting the topological nontriviality. These elements arise when exploring Cartan’s spinorial approach along with the exotic spinors counterpart. This evinced nontrivial topology corrections in the free particle dynamics and charged particles coupled to an external electromagnetic field. As a complement, we show the appearance of a magnetic monopole-like effect.