THE CONTENT OF POLYUNSATURATED FATTY ACIDS (PUFAS) IN MEMBRANES OF ERYTHROCYTES IN CHILDREN WITH ATOPIC DERMATITIS (AD) OF VARYING SEVERITY

Abstract

Currently, there is a hypothesis about the presence of congenital metabolic disorders of polyunsaturated fatty acids (PUFAs), which plays a role in the pathogenesis of atopic dermatitis. It is postulated deficit of deltafunction 6-desaturase, which leads to a lack of content in the cell membranes of derivatives of linoleic acid (gamma-linolenic acid (GLA) and arachidonic acid digomolinolenovoy). In addition, it is suggested a deficit of ω3-PUFA in atopic diseases. The composition of fatty acids of red blood cells in children with AD. Obtained by reduction of 14:0, 16:1 ω7, 18:1ω9 and 18:3ω6 (GLA) acids in erythrocyte membranes in children. The relationship between the level of GLA to the severity of AD. The complete absence of HCA in the membranes was detected in 83 % of children with severe AD, 60 % with mild AD and 41 % of healthy children, p1-3 = 0,033 It is suggested that the decrease in GLA in cell membranes may be the target of therapeutic intervention in children with AD. At the same time, our study found no evidence of ω3-PUFA deficiency in children with AD.

Keywords

• children
• atopy
• fatty acids
• erythrocytes