An investigation of cortical thickness and antidepressant response in major depressive disorder: A CAN-BIND study report

Jee Su Suh; Luciano Minuzzi; Pradeep Reddy Raamana; Andrew Davis; Geoffrey B. Hall; Jacqueline Harris; Stefanie Hassel; Mojdeh Zamyadi; Stephen R. Arnott; Gésine L. Alders; Roberto B. Sassi; Roumen Milev; Raymond W. Lam; Glenda M. MacQueen; Stephen C. Strother; Sidney H. Kennedy; Benicio N. Frey

NeuroImage: Clinical (Jan 2020)

An investigation of cortical thickness and antidepressant response in major depressive disorder: A CAN-BIND study report

Jee Su Suh,
Luciano Minuzzi,
Pradeep Reddy Raamana,
Andrew Davis,
Geoffrey B. Hall,
Jacqueline Harris,
Stefanie Hassel,
Mojdeh Zamyadi,
Stephen R. Arnott,
Gésine L. Alders,
Roberto B. Sassi,
Roumen Milev,
Raymond W. Lam,
Glenda M. MacQueen,
Stephen C. Strother,
Sidney H. Kennedy,
Benicio N. Frey

Affiliations

Jee Su Suh: Neuroscience Graduate Program, McMaster University, Hamilton, ON, Canada; Mood Disorders Program and Women's Health Concerns Clinic, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada
Luciano Minuzzi: Neuroscience Graduate Program, McMaster University, Hamilton, ON, Canada; Mood Disorders Program and Women's Health Concerns Clinic, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
Pradeep Reddy Raamana: Rotman Research Institute, Baycrest Health Sciences; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
Andrew Davis: Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, ON, Canada
Geoffrey B. Hall: Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, ON, Canada
Jacqueline Harris: Department of Computing Science, University of Alberta, Edmonton, AB, Canada
Stefanie Hassel: Department of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Mathison Centre for Mental Health Research and Education, University of Calgary, Calgary, AB, Canada
Mojdeh Zamyadi: Rotman Research Institute, Baycrest Health Sciences; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
Stephen R. Arnott: Rotman Research Institute, Baycrest Health Sciences; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
Gésine L. Alders: Neuroscience Graduate Program, McMaster University, Hamilton, ON, Canada; Mood Disorders Program and Women's Health Concerns Clinic, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada
Roberto B. Sassi: Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
Roumen Milev: Departments of Psychiatry and Psychology, Queen's University and Providence Care Hospital, Kingston, ON, Canada
Raymond W. Lam: Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
Glenda M. MacQueen: Department of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Mathison Centre for Mental Health Research and Education, University of Calgary, Calgary, AB, Canada
Stephen C. Strother: Rotman Research Institute, Baycrest Health Sciences; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
Sidney H. Kennedy: Canadian Biomarker Integration Network for Depression, St. Michael's Hospital, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada
Benicio N. Frey: Neuroscience Graduate Program, McMaster University, Hamilton, ON, Canada; Mood Disorders Program and Women's Health Concerns Clinic, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada; Corresponding author at: 100 West 5th Street, Suite C124, Hamilton, ON L8N 3K7 Canada.

Journal volume & issue: Vol. 25

Abstract

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Major depressive disorder (MDD) is considered a highly heterogeneous clinical and neurobiological mental disorder. We employed a novel layered treatment design to investigate whether cortical thickness features at baseline differentiated treatment responders from non-responders after 8 and 16 weeks of a standardized sequential antidepressant treatment. Secondary analyses examined baseline differences between MDD and controls as a replication analysis and longitudinal changes in thickness after 8 weeks of escitalopram treatment. 181 MDD and 95 healthy comparison (HC) participants were studied. After 8 weeks of escitalopram treatment (10–20 mg/d, flexible dosage), responders (>50% decrease in Montgomery-Åsberg Depression Scale score) were continued on escitalopram; non-responders received adjunctive aripiprazole (2–10 mg/d, flexible dosage). MDD participants were classified into subgroups according to their response profiles at weeks 8 and 16. Baseline group differences in cortical thickness were analyzed with FreeSurfer between HC and MDD groups as well as between response groups. Two-stage longitudinal processing was used to investigate 8-week escitalopram treatment-related changes in cortical thickness. Compared to HC, the MDD group exhibited thinner cortex in the left rostral middle frontal cortex [MNI(X,Y,Z=−29,9,54.5,−7.7); CWP=0.0002]. No baseline differences in cortical thickness were observed between responders and non-responders based on week-8 or week-16 response profile. No changes in cortical thickness was observed after 8 weeks of escitalopram monotherapy. In a two-step 16-week sequential clinical trial we found that baseline cortical thickness does not appear to be associated to clinical response to pharmacotherapy at 8 or 16 weeks. Keywords: Major depressive disorder, Cortical thickness, Structural neuroimaging, Antidepressant response, Clinical trial

Published in NeuroImage: Clinical

ISSN: 2213-1582 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General): Computer applications to medicine. Medical informatics; Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: http://www.journals.elsevier.com/neuroimage-clinical/

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