Health and Quality of Life Outcomes (May 2012)

Validation of a new tool to assess health-related quality of life in psoriasis: the PSO-LIFE questionnaire

  • Dauden Esteban,
  • Herrera Enrique,
  • Puig Lluis,
  • Sánchez-Carazo José,
  • Toribio Jaime,
  • Caloto Ma,
  • Nocea Gonzalo,
  • Roset Montse,
  • Lara Nuria

DOI
https://doi.org/10.1186/1477-7525-10-56
Journal volume & issue
Vol. 10, no. 1
p. 56

Abstract

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Abstract Background Several questionnaires have been used to measure health related quality of life (HRQoL) in patients with psoriasis, few have been adapted for use in Spain; none of them was developed specifically for the Spanish population. The purpose of the study was to validate and assess the sensitivity to change of a new questionnaire to measure HRQOL in patients with psoriasis (PSO-LIFE). Methods Observational, prospective, multicenter study performed in centers around Spain. Patients with active or inactive psoriasis completed the PSO-LIFE together with other Dermatology Quality of Life Index (DLQI) and Psoriasis Disability Index (PDI). A control group of patients with urticaria or atopic dermatitis was also included. Internal consistency and test-retest reliability of the PSO-LIFE were assessed by calculating Cronbach’s alpha and Intraclass Correlation Coefficient (ICC). Validity was assessed by examining factorial structure, the capacity to discriminate between groups, and correlations with other measures. Sensitivity to change was measured using effect sizes. Results The final sample included for analysis consisted of 304 patients and 56 controls. Mean (SD) age of psoriasis patients was 45.3 (14.5) years compared to 38.8 (14) years for controls (p Conclusions The present results provide substantial support for the reliability, validity, and responsiveness of the PSO-LIFE questionnaire in the population for which it was designed.

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