Synthesis of 6-Methoxy-1-oxaspiro[4,5]deca-6,9-diene-8-one

Abstract

The synthesis of a new spirolactone is described. The title compound is obtained as a white solid in 46% yield from 3-(4-hydroxy-2-methoxyphenyl)propanoic acid using [Bis(trifluoroacetoxy)iodo]benzene (PIFA) as the oxidant.

Keywords

• Spiroannulation
• oxidation
• phenol
• spirolactone
• PIFA