COVID-19 Infection in Autosomal Dominant Polycystic Kidney Disease and Chronic Kidney Disease Patients: Progression of Kidney Disease

Silvia Lai; Francesca Tinti; Adolfo Marco Perrotta; Luca Salomone; Rosario Cianci; Paolo Izzo; Sara Izzo; Luciano Izzo; Claudia De Intinis; Chiara Pellicano; Antonietta Gigante

doi:10.3390/biomedicines12061301

Biomedicines (Jun 2024)

COVID-19 Infection in Autosomal Dominant Polycystic Kidney Disease and Chronic Kidney Disease Patients: Progression of Kidney Disease

Silvia Lai,
Francesca Tinti,
Adolfo Marco Perrotta,
Luca Salomone,
Rosario Cianci,
Paolo Izzo,
Sara Izzo,
Luciano Izzo,
Claudia De Intinis,
Chiara Pellicano,
Antonietta Gigante

Affiliations

Silvia Lai: Department of Translational and Precision Medicine, UOC Nephrology, Sapienza University of Rome, 00185 Rome, Italy
Francesca Tinti: Department of Translational and Precision Medicine, UOC Nephrology, Sapienza University of Rome, 00185 Rome, Italy
Adolfo Marco Perrotta: Department of Translational and Precision Medicine, UOC Nephrology, Sapienza University of Rome, 00185 Rome, Italy
Luca Salomone: Department of Translational and Precision Medicine, UOC Nephrology, Sapienza University of Rome, 00185 Rome, Italy
Rosario Cianci: Department of Translational and Precision Medicine, UOC Nephrology, Sapienza University of Rome, 00185 Rome, Italy
Paolo Izzo: Department of Surgery “Pietro Valdoni”, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy
Sara Izzo: Plastic Surgery Unit, Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Luciano Izzo: Department of Surgery “Pietro Valdoni”, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy
Claudia De Intinis: Department of Surgery “Pietro Valdoni”, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, Italy
Chiara Pellicano: Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy
Antonietta Gigante: Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy

DOI: https://doi.org/10.3390/biomedicines12061301
Journal volume & issue: Vol. 12, no. 6
p. 1301

Abstract

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Introduction: the COVID-19 pandemic has brought to light the intricate interplay between viral infections and preexisting health conditions. In the field of kidney diseases, patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD) and Chronic Kidney Disease (CKD) face unique challenges when exposed to the SARS-CoV-2 virus. This study aims to evaluate whether SARS-CoV-2 virus infection impacts renal function differently in patients suffering from ADPKD and CKD when compared to patients suffering only from CKD. Materials and methods: clinical data from 103 patients were collected and retrospectively analyzed. We compared the renal function of ADPKD and CKD patients at two distinct time points: before COVID-19 infection (T0) and 1 year after the infection (T1). We studied also a subpopulation of 37 patients with an estimated glomerular filtration rate (eGFR) p p p p < 0.001) compared to CKD patients. Conclusion: the interplay between COVID-19 and kidney disease is complex. In CKD patients, the relationship between COVID-19 and kidney disease progression is more established, while limited studies exist on the specific impact of COVID-19 on ADPKD patients. Current evidence does not suggest that ADPKD patients are at a higher risk of SARS-CoV-2 infection; however, in our study we showed a significant worsening of the renal function among ADPKD patients, particularly those with an eGFR < 60 mL/min, in comparison to patients with only CKD after a one-year follow-up from COVID-19 infection.

Published in Biomedicines

ISSN: 2227-9059 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: http://www.mdpi.com/journal/biomedicines

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