Toxicological characteristics of dental gel ‘Matripin’

Abstract

We performed toxicological evaluation of dental gel ‘Matripin.’ Objective: to assess acute and chronic toxicity of dental gel ‘Matripin’ on mature rats. Animals were kept in standard vivarium conditions. Our findings suggest that ‘Matripin’ is a class 5 drug (virtually non-toxic substance). The assessment of chronic toxicity demonstrated that topical application of ‘Matripin’ does not have any toxic effects on the lungs, heart, spleen, liver, and kidneys, since morphological changes in these organs were similar in the experimental and control groups.

Keywords

• preclinical studies
• acute toxicity
• chronic toxicity
• chamomile extract
• poplar extract