Topical issues of diagnosis and treatment of alzheimer’s disease based on modern foreign guidelines

Abstract

The article highlights the issues of pharmacotherapy of Alzheimer’s disease based on the guidelines of the USA National Institute on Aging. It discusses the potential of early diagnosis in preclinical stages of the disease using laboratory and betaamyloid neuroimaging markers, neuronal damage. The role of NMDA receptors antagonist memantine in the regulation of excitotoxicity in dementia of the Alzheimer’s type was determined. The efficacy of memantine approved in the US and Europe for the treatment of moderate and severe Alzheimer’s disease is demonstrated. The paper notes its compatibility with other drugs used in the combination therapy, favourable safety profile and good drug tolerance.

Keywords

• alzheimer’s disease
• memantine
• foreign guidelines