Mechanisms of FLASH effect

Binwei Lin; Binwei Lin; Dan Huang; Feng Gao; Yiwei Yang; Dai Wu; Yu Zhang; Gang Feng; Tangzhi Dai; Xiaobo Du

doi:10.3389/fonc.2022.995612

Frontiers in Oncology (Sep 2022)

Mechanisms of FLASH effect

Binwei Lin,
Binwei Lin,
Dan Huang,
Feng Gao,
Yiwei Yang,
Dai Wu,
Yu Zhang,
Gang Feng,
Tangzhi Dai,
Xiaobo Du

Affiliations

Binwei Lin: National Health Commission (NHC) Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, Department of Oncology, Mianyang Central Hospital, Mianyang, China
Binwei Lin: State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China
Dan Huang: Department of Radiology Mianyang Central Hospital, Mianyang, China
Feng Gao: National Health Commission (NHC) Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, Department of Oncology, Mianyang Central Hospital, Mianyang, China
Yiwei Yang: Institute of Applied Electronics, China Academy of Engineering Physics, Mianyang, China
Dai Wu: Institute of Applied Electronics, China Academy of Engineering Physics, Mianyang, China
Yu Zhang: National Health Commission (NHC) Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, Department of Oncology, Mianyang Central Hospital, Mianyang, China
Gang Feng: National Health Commission (NHC) Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, Department of Oncology, Mianyang Central Hospital, Mianyang, China
Tangzhi Dai: National Health Commission (NHC) Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, Department of Oncology, Mianyang Central Hospital, Mianyang, China
Xiaobo Du: National Health Commission (NHC) Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, Department of Oncology, Mianyang Central Hospital, Mianyang, China

DOI: https://doi.org/10.3389/fonc.2022.995612
Journal volume & issue: Vol. 12

Abstract

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FLASH radiotherapy (FLASH-RT) is a novel radiotherapy technology defined as ultra-high dose rate (≥ 40 Gy/s) radiotherapy. The biological effects of FLASH-RT include two aspects: first, compared with conventional dose rate radiotherapy, FLASH-RT can reduce radiation-induced damage in healthy tissue, and second, FLASH-RT can retain antitumor effectiveness. Current research shows that mechanisms of the biological effects of FLASH-RT are related to oxygen. However, due to the short time of FLASH-RT, evidences related to the mechanisms are indirect, and the exact mechanisms of the biological effects of FLASH-RT are not completely clear and some are even contradictory. This review focuses on the mechanisms of the biological effects of FLASH-RT and proposes future research directions.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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