Nature Communications (Nov 2016)

Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies

  • Yukinori Hirano,
  • Kunio Ihara,
  • Tomoko Masuda,
  • Takuya Yamamoto,
  • Ikuko Iwata,
  • Aya Takahashi,
  • Hiroko Awata,
  • Naosuke Nakamura,
  • Mai Takakura,
  • Yusuke Suzuki,
  • Junjiro Horiuchi,
  • Hiroyuki Okuno,
  • Minoru Saitoe

DOI
https://doi.org/10.1038/ncomms13471
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

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Transcriptional regulation is necessary for maintaining long-term memories (LTM) but the mechanistic details are not completely defined. Here the authors identify transcriptional machinery and histone modifiers required for LTM maintenance inDrosophilaand show that transcriptional regulation for LTM maintenance is distinct from that for LTM formation.