mBio
(Oct 2021)
Cryo-Electron Microscopy Structure and Interactions of the Human Cytomegalovirus gHgLgO Trimer with Platelet-Derived Growth Factor Receptor Alpha
Jing Liu,
Adam Vanarsdall,
Dong-Hua Chen,
Andrea Chin,
David Johnson,
Theodore S. Jardetzky
Affiliations
Jing Liu
Department of Structural Biology, Stanford University School of Medicine, Stanford, California, USA
Adam Vanarsdall
Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, Oregon, USA
Dong-Hua Chen
Department of Structural Biology, Stanford University School of Medicine, Stanford, California, USA
Andrea Chin
Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, Oregon, USA
David Johnson
ORCiD Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, Oregon, USA
Theodore S. Jardetzky
Department of Structural Biology, Stanford University School of Medicine, Stanford, California, USA
DOI
https://doi.org/10.1128/mBio.02625-21
Journal volume & issue
Vol. 12,
no. 5
Abstract
Read online
HCMV is a herpesvirus that infects a large percentage of the adult population and causes significant levels of disease in immunocompromised individuals and birth defects in the developing fetus. The virus encodes a complex protein machinery that coordinates infection of different cell types in the body, including a trimer formed of gH, gL, and gO subunits.
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