Nature Communications (Aug 2016)

Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs

  • Maoyi Lai,
  • Alicia Gonzalez-Martin,
  • Anthony B. Cooper,
  • Hiroyo Oda,
  • Hyun Yong Jin,
  • Jovan Shepherd,
  • Linling He,
  • Jiang Zhu,
  • David Nemazee,
  • Changchun Xiao

DOI
https://doi.org/10.1038/ncomms12207
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 13

Abstract

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MicroRNA cluster 17∼92 plays a critical role in B-cell differentiation. Here the authors show that miR-19 regulates B-cell tolerance via suppressing the expression of PTEN, whereas miR- 17 is essential for early B-cell development independently of Pten, Phlpp2, or Bim.