IEEE Open Journal of Engineering in Medicine and Biology (Jan 2024)
Grand Challenges at the Interface of Engineering and Medicine
- Shankar Subramaniam,
- Metin Akay,
- Mark A. Anastasio,
- Vasudev Bailey,
- David Boas,
- Paolo Bonato,
- Ashutosh Chilkoti,
- Jennifer R. Cochran,
- Vicki Colvin,
- Tejal A. Desai,
- James S. Duncan,
- Frederick H. Epstein,
- Stephanie Fraley,
- Cecilia Giachelli,
- K. Jane Grande-Allen,
- Jordan Green,
- X. Edward Guo,
- Isaac B. Hilton,
- Jay D. Humphrey,
- Chris R Johnson,
- George Karniadakis,
- Michael R. King,
- Robert F. Kirsch,
- Sanjay Kumar,
- Cato T. Laurencin,
- Song Li,
- Richard L. Lieber,
- Nigel Lovell,
- Prashant Mali,
- Susan S. Margulies,
- David F. Meaney,
- Brenda Ogle,
- Bernhard Palsson,
- Nicholas A. Peppas,
- Eric J. Perreault,
- Rick Rabbitt,
- Lori A. Setton,
- Lonnie D. Shea,
- Sanjeev G. Shroff,
- Kirk Shung,
- Andreas S. Tolias,
- Marjolein C.H. van der Meulen,
- Shyni Varghese,
- Gordana Vunjak-Novakovic,
- John A. White,
- Raimond Winslow,
- Jianyi Zhang,
- Kun Zhang,
- Charles Zukoski,
- Michael I. Miller
Affiliations
- Shankar Subramaniam
- ORCiD
- Joan and Irwin Jacobs Endowed Chair in Bioengineering and Systems Biology, Distinguished Professor of Bioengineering, Computer Science & Engineering, Cellular & Molecular Medicine, and Nanoengineering, University of California San Diego, La Jolla, CA, USA
- Metin Akay
- ORCiD
- Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Charlestown, MA, USA
- Mark A. Anastasio
- ORCiD
- Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Charlestown, MA, USA
- Vasudev Bailey
- ORCiD
- Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Charlestown, MA, USA
- David Boas
- ORCiD
- Professor of Biomedical Engineering and Director of Neurophotonics Center, Boston University College of Engineering, Boston, MA, USA
- Paolo Bonato
- ORCiD
- Department of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Charlestown, MA, USA
- Ashutosh Chilkoti
- ORCiD
- Alan L. Kaganov Professor of Biomedical Engineering and Chair of the Department of Biomedical Engineering, Duke University, Durham, NC, USA
- Jennifer R. Cochran
- ORCiD
- Senior Associate Vice Provost for Research and Addie and Al Macovski Professor of Bioengineering, Shriram Center, Stanford University Schools of Medicine and Engineering, Stanford, CA, USA
- Vicki Colvin
- ORCiD
- Vernon K Krieble Professor of Chemistry and Professor of Engineering, Brown University, Providence, RI, USA
- Tejal A. Desai
- ORCiD
- Sorensen Family Dean of Engineering and Professor of Engineering, Brown University, Providence, RI, USA
- James S. Duncan
- ORCiD
- Ebenezer K. Hunt Professor and Chair of Biomedical Engineering, Professor of Radiology & Biomedical Imaging, Yale University, New Haven, CT, USA
- Frederick H. Epstein
- ORCiD
- Mac Wade Professor of Biomedical Engineering and Professor of Radiology and Medical Imaging, Associate Dean for Research, School of Engineering and Applied Science, Charlottesville, VA, USA
- Stephanie Fraley
- ORCiD
- Associate Professor of Bioengineering, University of California San Diego, La Jolla, CA, USA
- Cecilia Giachelli
- ORCiD
- Steven R. and Connie R. Rogel Endowed Professor for Cardiovascular Innovation in Bioengineering, Associate Vice Provost for Research, Seattle, WA, USA
- K. Jane Grande-Allen
- ORCiD
- Isabel C. Cameron Professor of Bioengineering, Department of Bioengineering, Rice University, Houston, TX, USA
- Jordan Green
- ORCiD
- Biomedical Engineering and Vice Chair for Research and Translation, Department of Biomedical Engineering, Baltimore, MD, USA
- X. Edward Guo
- ORCiD
- Professor of Biomedical Engineering and Department Chair, New York, NY, USA
- Isaac B. Hilton
- ORCiD
- Assistant Professor of Bioengineering and BioSciences, Rice University, Houston, TX, USA
- Jay D. Humphrey
- ORCiD
- John C. Malone Professor of Biomedical Engineering, Yale University, New Haven, CT, USA
- Chris R Johnson
- ORCiD
- Distinguished Professor of Computer Science, Research Professor of Bioengineering, University of Utah, Salt Lake City, UT, USA
- George Karniadakis
- ORCiD
- The Charles Pitts Robinson and John Palmer Barstow Professor of Applied Mathematics and Engineering, Brown University, Providence, RI, USA
- Michael R. King
- ORCiD
- J. Lawrence Wilson Professor of Engineering, Chair, Department of Biomedical Engineering, Professor of Biomedical Engineering, Professor of Radiology and Radiological Sciences, 5824 Stevenson Center, Nashville, TN, USA
- Robert F. Kirsch
- ORCiD
- Allen H. and Constance T. Ford Professor and Chair of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA
- Sanjay Kumar
- ORCiD
- California Institute for Quantitative Biosciences, UC Berkeley, Berkeley, CA, USA
- Cato T. Laurencin
- ORCiD
- University Professor and Albert and Wilda Van Dusen Distinguished Endowed Professor of Orthopaedic Surgery, CEO, The Cato T. Laurencin Institute for Regenerative Engineering, Uconn, Farmington, CT, USA
- Song Li
- ORCiD
- Department of Bioengineering, UCLA Samueli School of Engineering, Los Angeles, CA, USA
- Richard L. Lieber
- ORCiD
- Chief Scientific Officer and Senior Vice President, Shirley Ryan Ability Lab, Professor of Physiology and Biomedical Engineering, Northwestern University, Evanston, IL, USAUSA
- Nigel Lovell
- ORCiD
- Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW, Australia
- Prashant Mali
- ORCiD
- Professor of Bioengineering, University of California San Diego, La Jolla, CA, USA
- Susan S. Margulies
- ORCiD
- Wallace H. Coulter Chair and Professor of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA
- David F. Meaney
- ORCiD
- Professor and Senior Associate Dean, Penn Engineering, Philadelphia, PA, USA
- Brenda Ogle
- ORCiD
- Department of Biomedical Engineering, Professor, Department of Pediatrics, Director, Stem Cell Institute, University of Minnesota-Twin Cities, Minneapolis, MN, USA
- Bernhard Palsson
- ORCiD
- Y.C. Fung Endowed Professor in Bioengineering, Professor of Pediatrics, University of California San Diego, La Jolla, CA, USA
- Nicholas A. Peppas
- ORCiD
- Cockrell Family Regents Chair in Engineering, Director, Institute of Biomaterials, Drug Delivery and Regenerative Medicine, Professor, McKetta Department of Chemical Engineering, Department of Biomedical Engineering, Department of Pediatrics, Department of Surgery and Perioperative Care, Dell Medical School, and Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX, USA
- Eric J. Perreault
- ORCiD
- Vice President for Research, Professor of Biomedical Engineering, Professor of Physical Medicine and Rehabilitation, Northwestern University, Evanston, IL, USA
- Rick Rabbitt
- ORCiD
- Professor of Biomedical Engineering, Neuroscience Program, Sal Lake City, UT, USA
- Lori A. Setton
- ORCiD
- Department Chair, Lucy & Stanley Lopata Distinguished Professor of Biomedical Engineering, Washington University in St. Louis, McKelvey School of Engineering, St. Louis, MO, USA
- Lonnie D. Shea
- ORCiD
- Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA
- Sanjeev G. Shroff
- ORCiD
- Distinguished Professor of and Gerald E. McGinnis Chair in Bioengineering, Professor of Medicine, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA
- Kirk Shung
- ORCiD
- Professor Emeritus of Biomedical Engineering, Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA
- Andreas S. Tolias
- ORCiD
- Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA
- Marjolein C.H. van der Meulen
- ORCiD
- Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA
- Shyni Varghese
- ORCiD
- Professor of Biomedical Engineering, Mechanical Engineering & Materials Science and Orthopaedics, Duke University, Durham, NC, USA
- Gordana Vunjak-Novakovic
- ORCiD
- University and Mikati Foundation Professor of Biomedical Engineering and Medical Sciences, Columbia University, New York, NY, USA
- John A. White
- ORCiD
- Professor and Chair Department of Biomedical Engineering, Boston University, Boston, MA, USA
- Raimond Winslow
- ORCiD
- Director of Life Science and Medical Research; Professor of Bioengineering, Northeastern University, Portland, ME, USA
- Jianyi Zhang
- ORCiD
- Department of Biomedical Engineering, T. Michael and Gillian Goodrich Endowed Chair of Engineering Leadership, Professor of Medicine, of Engineering, School of Medicine, School of Engineering, UAB | The University of Alabama at Birmingham, U.K.
- Kun Zhang
- ORCiD
- Chair/Professor of Bioengineering, University of California San Diego, La Jolla, CA, USA
- Charles Zukoski
- ORCiD
- Shelly and Ofer Nemirovsky Provost's Chair and Professor of Chemical Engineering and Materials Science and Biomedical Engineering, Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA
- Michael I. Miller
- ORCiD
- Bessie Darling Massey Professor and Director, Department of Biomedical Engineering, Co-Director, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, MD, USA
- DOI
- https://doi.org/10.1109/OJEMB.2024.3351717
- Journal volume & issue
-
Vol. 5
pp. 1 – 13
Abstract
Over the past two decades Biomedical Engineering has emerged as a major discipline that bridges societal needs of human health care with the development of novel technologies. Every medical institution is now equipped at varying degrees of sophistication with the ability to monitor human health in both non-invasive and invasive modes. The multiple scales at which human physiology can be interrogated provide a profound perspective on health and disease. We are at the nexus of creating “avatars” (herein defined as an extension of “digital twins”) of human patho/physiology to serve as paradigms for interrogation and potential intervention. Motivated by the emergence of these new capabilities, the IEEE Engineering in Medicine and Biology Society, the Departments of Biomedical Engineering at Johns Hopkins University and Bioengineering at University of California at San Diego sponsored an interdisciplinary workshop to define the grand challenges that face biomedical engineering and the mechanisms to address these challenges. The Workshop identified five grand challenges with cross-cutting themes and provided a roadmap for new technologies, identified new training needs, and defined the types of interdisciplinary teams needed for addressing these challenges. The themes presented in this paper include: 1) accumedicine through creation of avatars of cells, tissues, organs and whole human; 2) development of smart and responsive devices for human function augmentation; 3) exocortical technologies to understand brain function and treat neuropathologies; 4) the development of approaches to harness the human immune system for health and wellness; and 5) new strategies to engineer genomes and cells.
Keywords
- Genome-engineering
- human function augmentation
- immuno-engineering
- precision medicine
- digital twins
- neuroimaging
