Periocular Infection of <i>Mycobacterium avium</i> Complex in a Patient with Interferon-γ Autoantibodies: A Case Report
Tzu-Hui Lo,
Tou-Yuan Tsai,
Lih-Shinn Wang,
Tzu-Lun Huang,
Nancy Chen
Affiliations
Tzu-Hui Lo
Division of Plastic and Reconstructive Surgery, Department of Surgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan
Tou-Yuan Tsai
School of Medicine, Tzu Chi University, Hualien 970, Taiwan
Lih-Shinn Wang
Division of Infectious Disease, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan
Tzu-Lun Huang
Department of Ophthalmology, Far Eastern Memorial Hospital, Banqiao Dist., New Taipei City 220, Taiwan
Nancy Chen
Departments of Ophthalmology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970, Taiwan
The neutralizing anti-interferon-γ autoantibody (nAIGA)-associated immunodeficiency is an emerging entity frequently associated with the nontuberculosis mycobacterium (NTM) infection and other opportunistic infections. We present a female patient with a mysterious periocular Mycobacterium avium complex (MAC) infection, accompanied by sequential opportunistic infections including Salmollelosis and herpes zoster infection. Her condition stabilized after long-term antimycobacterial treatment. Nevertheless, neutralizing anti-interferon-γ autoantibody was found in her serum, which was compatible with the scenario of adult-onset immunodeficiency.
