Renal affection among type 2 diabetic patients and their families

Abstract

Background and Aim It was believed that both environmental and genetic factors are involved in the pathogenesis of tyrje 2 diabetes mellitus (T2DM). We aimed to figure out the renal affection in patients with T2DM and their family relatives. Patients and methods The current study included 80 patients with T2DM without history of kidney diseases and 80 family members of the diabetic patients neither known to be diabetic nor had kidney diseases compared with 80 apparently healthy persons as a normal control group without a family history of diabetes. Results The prevalence of microvascular complications in diabetic patients and their relatives was as follows: nephropathy (27.5 and 5%, respectively), neuropathy (30 and 8.75%, respectively), and retinopathy (18.83 and 6.2%, respectively). Overall, 22.5% of the relatives had metabolic srtndrome. Microvascular complications of diabetes were associated with longer disease duration, elevated blood pressure, and poor glycemic control, whereas microvascular complications in relatives were associated with one or more of t.he metabolic components of metabolic syndrome. Conclusion screening of diabetic patients for microvascular complications is mandatory as early as possible.The detection of the metabolic components in T2 diabetic relatives can predict the prediabetic state and also can predict the possible occurrence of microvascular complications before happening, and early management can delay them.

Keywords

• diabetic nephropathy; diabetic relatives; metabolic syndrome; type 2 diabetes