Locally anchoring enzymes to tissues via extracellular glycan recognition

Shaheen A. Farhadi; Evelyn Bracho-Sanchez; Margaret M. Fettis; Dillon T. Seroski; Sabrina L. Freeman; Antonietta Restuccia; Benjamin G. Keselowsky; Gregory A. Hudalla

doi:10.1038/s41467-018-07129-6

Nature Communications (Nov 2018)

Locally anchoring enzymes to tissues via extracellular glycan recognition

Shaheen A. Farhadi,
Evelyn Bracho-Sanchez,
Margaret M. Fettis,
Dillon T. Seroski,
Sabrina L. Freeman,
Antonietta Restuccia,
Benjamin G. Keselowsky,
Gregory A. Hudalla

Affiliations

Shaheen A. Farhadi: J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida
Evelyn Bracho-Sanchez: J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida
Margaret M. Fettis: J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida
Dillon T. Seroski: J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida
Sabrina L. Freeman: J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida
Antonietta Restuccia: J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida
Benjamin G. Keselowsky: J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida
Gregory A. Hudalla: J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida

DOI: https://doi.org/10.1038/s41467-018-07129-6
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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The use of enzymes as drugs requires that they persist within target tissues over therapeutically relevant time frames. Here the authors use a galectin-3 fusion to anchor enzymes at injection sites for up to 14 days.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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