Indian Journal of Psychological Medicine (Jan 2017)

Chlorpromazine as prophylaxis for bipolar disorder with treatment- and electroconvulsive therapy-refractory mania: Old horse, new trick

  • Tamonud Modak,
  • Saurabh Kumar,
  • Arghya Pal,
  • Rishab Gupta,
  • Raman Deep Pattanayak,
  • Sudhir Kumar Khandelwal

DOI
https://doi.org/10.4103/0253-7176.211759
Journal volume & issue
Vol. 39, no. 4
pp. 539 – 541

Abstract

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A 22-year-old male diagnosed with bipolar affective disorder presented to us with a 3rd episode mania resistant to both olanzapine and haloperidol as well as electroconvulsive therapy. He, however, responded to chlorpromazine (CPZ) which was also effective as a mood stabilizer. The patient had a relapse of his illness when CPZ was stopped and responded again when it was started. The case demonstrates that CPZ may have a role in as both an anti-manic agent and for the maintenance for bipolar disorders. The possible underlying mechanism for this role is also discussed.

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