Frontiers in Pharmacology (2021-02-01)

Several FDA-Approved Drugs Effectively Inhibit SARS-CoV-2 Infection in vitro

  • Hua-Long Xiong,
  • Jia-Li Cao,
  • Jia-Li Cao,
  • Chen-Guang Shen,
  • Chen-Guang Shen,
  • Jian Ma,
  • Xiao-Yang Qiao,
  • Tian-Shu Shi,
  • Sheng-Xiang Ge,
  • Hui-Ming Ye,
  • Jun Zhang,
  • Quan Yuan,
  • Tian-Ying Zhang,
  • Ning-Shao Xia

DOI
https://doi.org/10.3389/fphar.2020.609592
Journal volume & issue
Vol. 11

Abstract

Read online

To identify drugs that are potentially used for the treatment of COVID-19, the potency of 1403 FDA-approved drugs were evaluated using a robust pseudovirus assay and the candidates were further confirmed by authentic SARS-CoV-2 assay. Four compounds, Clomiphene (citrate), Vortioxetine, Vortioxetine (hydrobromide) and Asenapine (hydrochloride), showed potent inhibitory effects in both pseudovirus and authentic virus assay. The combination of Clomiphene (citrate), Vortioxetine and Asenapine (hydrochloride) is much more potent than used alone, with IC50 of 0.34 μM.

Keywords