Nature Communications (May 2020)
Lymphocyte predominant cells detect Moraxella catarrhalis-derived antigens in nodular lymphocyte-predominant Hodgkin lymphoma
- Lorenz Thurner,
- Sylvia Hartmann,
- Natalie Fadle,
- Evi Regitz,
- Maria Kemele,
- Yoo-Jin Kim,
- Rainer Maria Bohle,
- Anna Nimmesgern,
- Lutz von Müller,
- Volkhard A. J. Kempf,
- Marc A. Weniger,
- Frank Neumann,
- Nadine Schneider,
- Martine Vornanen,
- Christer Sundström,
- Laurence de Leval,
- Andreas Engert,
- Dennis A. Eichenauer,
- Ralf Küppers,
- Klaus-Dieter Preuss,
- Martin-Leo Hansmann,
- Michael Pfreundschuh
Affiliations
- Lorenz Thurner
- José Carreras Center for Immuno- and Gene Therapy and Internal Medicine I, Saarland University Medical School
- Sylvia Hartmann
- Dr. Senckenberg Institute of Pathology, Goethe University
- Natalie Fadle
- José Carreras Center for Immuno- and Gene Therapy and Internal Medicine I, Saarland University Medical School
- Evi Regitz
- José Carreras Center for Immuno- and Gene Therapy and Internal Medicine I, Saarland University Medical School
- Maria Kemele
- José Carreras Center for Immuno- and Gene Therapy and Internal Medicine I, Saarland University Medical School
- Yoo-Jin Kim
- Saarland University Medical School, Institute of Pathology
- Rainer Maria Bohle
- Saarland University Medical School, Institute of Pathology
- Anna Nimmesgern
- Institute of Medical Microbiology and Hygiene, University of Saarland
- Lutz von Müller
- German National Reference Center for Clostridoides (Clostridium) difficile, Institute for Laboratory Medicine, Microbiology and Hygiene, Christophorus Kliniken
- Volkhard A. J. Kempf
- Institute of Medical Microbiology and Infection Control, University Hospital of the Goethe University
- Marc A. Weniger
- Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Medical School
- Frank Neumann
- José Carreras Center for Immuno- and Gene Therapy and Internal Medicine I, Saarland University Medical School
- Nadine Schneider
- Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine & Pharmacology, and Division of Rheumatology, University Hospital Frankfurt Goethe University
- Martine Vornanen
- Department of Pathology, Tampere University Hospital and University of Tampere
- Christer Sundström
- Department of Immunology, Genetics and Pathology, Uppsala University Hospital
- Laurence de Leval
- Institute of Pathology, Lausanne University Hospital
- Andreas Engert
- University of Cologne, First Department of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf
- Dennis A. Eichenauer
- University of Cologne, First Department of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf
- Ralf Küppers
- Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Medical School
- Klaus-Dieter Preuss
- José Carreras Center for Immuno- and Gene Therapy and Internal Medicine I, Saarland University Medical School
- Martin-Leo Hansmann
- Dr. Senckenberg Institute of Pathology, Goethe University
- Michael Pfreundschuh
- José Carreras Center for Immuno- and Gene Therapy and Internal Medicine I, Saarland University Medical School
- DOI
- https://doi.org/10.1038/s41467-020-16375-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Nodular lymphocyte-predominant Hodgkin lymphoma with IgD+ lymphocyte-predominant (LP) cells is a rare clinical distinct lymphoma subset of B-cell origin. Here the authors show that antigens expressed by Moraxella catarrhalis are recognized by B cell receptors of IgD+ LP cells, suggesting the contribution of chronic antigen stimulation to lymphomagenesis.
