Type 2 diabetes mellitus: time to change the concept

Abstract

Diabetes mellitus is a heterogeneous group of diseases that, although unified by a number of characteristics, require a differential thera- peutic approach. Current review discusses key pathogenic features of type 2 diabetes mellitus that determine therapy goals and options in management. We further enunciate and pathogenetically substantiate a new "gravicentric" concept for treatment of type 2 diabetes mellitus that differs in many ways from the common contemporary approach.

Keywords

• type 2 diabetes mellitus
• body mass
• obesity
• insulin
• incretins
• bariatric surgery
• cardiovascular mortality
• remission