Nature Communications (Jan 2020)

Differential expansion of T central memory precursor and effector subsets is regulated by division speed

  • Lorenz Kretschmer,
  • Michael Flossdorf,
  • Jonas Mir,
  • Yi-Li Cho,
  • Marten Plambeck,
  • Irina Treise,
  • Albulena Toska,
  • Susanne Heinzel,
  • Matthias Schiemann,
  • Dirk H. Busch,
  • Veit R. Buchholz

Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12


Read online

T cell responses start with antigen-induced rapid cell divisions, and end by division cessation after pathogen clearance. Here, the authors use single-cell fate mapping and nucleoside analogue labelling to show that T central memory precursors proliferate slower than effector subsets and rely on antigenic rather than inflammatory stimuli to maintain their cell cycle speed.