P6.4 PLATELET ACTIVITY IN TEENAGE BOYS WITH PRIMARY ARTERIAL HYPERTENSION

Abstract

Objective: Primary arterial hypertenion for teen has caused a lot of debate today, there is too much uncertainty about platelet functional changes in patients with PAH. The objective was to evaluate platelet activity in healthy and suffering from PAH groups of 17–18 year old boys. Materials and methods: Platelet functional activity was determined by flow cytometry. Platelets used to identify the three antibodies: CD42a (GP IX), CD41a (GP IIb) and CD61 (GP IIIa) and assessing the activity of select PAC-1 antibody that binds specifically to activated GPIIb / IIIa complex. Through 2008–2013 years platelet activity was assessed 38 PAH 17–18 year-old boys (case group) and 41 healthy the same age teenager (control group). A statistical analysis was done and the significance assessed by a X-square test. The statistical difference was considered significant if the p value was below 0.05. Results: In PAH group of teen boys were not found statistically significantly more PAC-1 antibody attaghed platelets. Based on the results of this study we could argue that the platelet functional activity of PAH teens is not higher than in healthy adolescents. Conclusions: PAH teen platelet functional activity does not differ from healthy peers. To obtain accurate results, it should be performed at a higher sample survey.

Keywords

• primary arterial hypertension
• platelet activity