Oncofertility in women cured of hodgkin’s lymphoma as a child

Abstract

The concept of risk-adapted therapy is a modern standard of choice for the treatment regimen of Hodgkin’s lymphoma in childhood. As a rule, patients are distributed depending on the number of factors in the groups of low, intermediate and high risk with a particular volume of the treatment program. The rational use of chemotherapy and radiation therapy can reduce the risk of gonadal toxicity. Loss of oocytes in patients receiving Hodgkin’s lymphoma therapy in childhood is usually associated with systemic chemotherapy and pelvic irradiation. A combination of inhibin B and FSH is proposed as a screening marker to assess the gonadotoxic effects of chemotherapy, in both girls and boys.

Keywords

• girls
• women
• hodgkin’s lymphoma
• gonadotoxicity
• fertility
• alkylating drugs
• radiation therapy