Oculogyric Crisis Associated with Disulfiram-Induced Pallidonigral Lesion

Abstract

We report a man who developed oculogyric crisis one month after disulfiram intoxication. Brain MRI showed lesions involving bilateral globus pallidus and left substantia nigra. In our patient, neuronal discharges from pathologically reorganized basal ganglia circuit to the mid-brain ocular motor center might lead to tonic deviation of the eyes.

Keywords

• Disulfiram
• Oculogyric crisis