Nature Communications (Jan 2023)

Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape

  • Leander Witte,
  • Viren A. Baharani,
  • Fabian Schmidt,
  • Zijun Wang,
  • Alice Cho,
  • Raphael Raspe,
  • Camila Guzman-Cardozo,
  • Frauke Muecksch,
  • Marie Canis,
  • Debby J. Park,
  • Christian Gaebler,
  • Marina Caskey,
  • Michel C. Nussenzweig,
  • Theodora Hatziioannou,
  • Paul D. Bieniasz

DOI
https://doi.org/10.1038/s41467-023-35927-0
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 11

Abstract

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Witte et al show that previously acquired substitutions in the SARS-CoV-2 spike protein enable the acquisition of new antibody escape substitutions. New and old substitutions interact to enable escape from broadly neutralizing antibodies.