Journal of Clinical Medicine (Jan 2023)
Gender Difference in the Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry
- Giuseppe De Luca,
- Stephane Manzo-Silberman,
- Magdy Algowhary,
- Berat Uguz,
- Dinaldo C. Oliveira,
- Vladimir Ganyukov,
- Oliver Busljetik,
- Miha Cercek,
- Lisette Okkels,
- Poay Huan Loh,
- Lucian Calmac,
- Gerard Roura i Ferrer,
- Alexandre Quadros,
- Marek Milewski,
- Fortunato Scotto di Uccio,
- Clemens von Birgelen,
- Francesco Versaci,
- Jurrien Ten Berg,
- Gianni Casella,
- Aaron Wong Sung Lung,
- Petr Kala,
- José Luis Díez Gil,
- Xavier Carrillo,
- Maurits Dirksen,
- Victor Becerra,
- Michael Kang-yin Lee,
- Dafsah Arifa Juzar,
- Rodrigo de Moura Joaquim,
- Roberto Paladino,
- Davor Milicic,
- Periklis Davlouros,
- Nikola Bakraceski,
- Filippo Zilio,
- Luca Donazzan,
- Adriaan Kraaijeveld,
- Gennaro Galasso,
- Lux Arpad,
- Lucia Marinucci,
- Vincenzo Guiducci,
- Maurizio Menichelli,
- Alessandra Scoccia,
- Aylin Hatice Yamac,
- Kadir Ugur Mert,
- Xacobe Flores Rios,
- Tomas Kovarnik,
- Michal Kidawa,
- Josè Moreu,
- Vincent Flavien,
- Enrico Fabris,
- Iñigo Lozano Martínez-Luengas,
- Marco Boccalatte,
- Francisco Bosa Ojeda,
- Carlos Arellano-Serrano,
- Gianluca Caiazzo,
- Giuseppe Cirrincione,
- Hsien-Li Kao,
- Juan Sanchis Forés,
- Luigi Vignali,
- Helder Pereira,
- Santiago Ordoñez,
- Alev Arat Özkan,
- Bruno Scheller,
- Heidi Lehtola,
- Rui Teles,
- Christos Mantis,
- Ylitalo Antti,
- João António Brum Silveira,
- Cesar Rodrigo Zoni,
- Ivan Bessonov,
- Giuseppe Uccello,
- George Kochiadakis,
- Dimitrios Alexopulos,
- Carlos E. Uribe,
- John Kanakakis,
- Benjamin Faurie,
- Gabriele Gabrielli,
- Alejandro Gutierrez Barrios,
- Juan Pablo Bachini,
- Alex Rocha,
- Frankie C. C. Tam,
- Alfredo Rodriguez,
- Antonia Anna Lukito,
- Veauthyelau Saint-Joy,
- Gustavo Pessah,
- Andrea Tuccillo,
- Alfonso Ielasi,
- Giuliana Cortese,
- Guido Parodi,
- Mohamed Abed Bouraghda,
- Marcia Moura,
- Elvin Kedhi,
- Pablo Lamelas,
- Harry Suryapranata,
- Matteo Nardin,
- Monica Verdoia
Affiliations
- Giuseppe De Luca
- Division of Cardiology, AOU “Policlinico G. Martino”, Department of Clinical and Experimental Medicine, University of Messina, 98124 Messina, Italy
- Stephane Manzo-Silberman
- ACTION Study Group, Institute of Cardiology—Hôpital Pitié-Salpêtrière (AP-HP), Sorbonne University, 75651 Paris, France
- Magdy Algowhary
- Division of Cardiology, Assiut University Heart Hospital, Assiut University, Asyut 71515, Egypt
- Berat Uguz
- Division of Cardiology, Bursa City Hospital, 16000 Bursa, Turkey
- Dinaldo C. Oliveira
- Pronto de Socorro Cardiologico Prof. Luis Tavares, Centro PROCAPE, Federal University of Pernambuco, Recife 50670-901, Brazil
- Vladimir Ganyukov
- Department of Heart and Vascular Surgery, State Research Institute for Complex Issues of Cardiovascular Diseases, 650000 Kemerovo, Russia
- Oliver Busljetik
- University Clinic for Cardiology, Medical Faculty, Ss’ Cyril and Methodius University, 1000 Skopje, North Macedonia
- Miha Cercek
- Department of Cardiology, Medical Center Ljubljana, 1000 Ljubljana, Slovenia
- Lisette Okkels
- Division of Cardiology, Odense Universitets Hospital, 5000 Odense, Denmark
- Poay Huan Loh
- Department of Cardiology, National University Hospital, Singapore 117597, Singapore
- Lucian Calmac
- Clinic Emergency Hospital of Bucharest, 014461 Bucharest, Romania
- Gerard Roura i Ferrer
- Interventional Cardiology Unit, Heart Disease Institute, Hospital Universitari de Bellvitge, 08016 Barcelona, Spain
- Alexandre Quadros
- Instituto de Cardiologia do Rio Grande do Sul, Porto Alegre 90040-371, Brazil
- Marek Milewski
- Division of Cardiology, Medical University of Silezia, 40-002 Katowice, Poland
- Fortunato Scotto di Uccio
- Division of Cardiology, Ospedale del Mare, 00156 Napoli, Italy
- Clemens von Birgelen
- Department of Cardiology, Medisch Spectrum Twente, Thoraxcentrum Twente, 7541 Enschede, The Netherlands
- Francesco Versaci
- Division of Cardiology, Ospedale Santa Maria Goretti Latina, 04100 Latina, Italy
- Jurrien Ten Berg
- Division of Cardiology, St. Antonius Hospital, 3434 Nieuwegein, The Netherlands
- Gianni Casella
- Division of Cardiology, Ospedale Maggiore Bologna, 40100 Bologna, Italy
- Aaron Wong Sung Lung
- Department of Cardiology, National Heart Center, Singapore 169609, Singapore
- Petr Kala
- University Hospital Brno, Medical Faculty of Masaryk University, 60200 Brno, Czech Republic
- José Luis Díez Gil
- Sección de la Unidad de Hemodinámica H. Universitario y Politécnico La Fe, 46001 Valencia, Spain
- Xavier Carrillo
- Hospital Germans Triasi Pujol, 8918 Badalona, Spain
- Maurits Dirksen
- Division of Cardiology, Northwest Clinics, 1811 Alkmaar, The Netherlands
- Victor Becerra
- Hospital Clínico Universitario Virgen de la Victoria, 29000 Malaga, Spain
- Michael Kang-yin Lee
- Department of Cardiology, Queen Elizabeth Hospital, University of Hong Kong, Hong Kong
- Dafsah Arifa Juzar
- Department of Cardiology and Vascular Medicine, University of Indonesia National Cardiovascular Center “Harapan Kita”, Jakarta 11420, Indonesia
- Rodrigo de Moura Joaquim
- Instituto de Cardiologia de Santa Catarina Praia Comprida, São José 88103-901, Brazil
- Roberto Paladino
- Division of Cardiology, Clinica Villa dei Fiori, 80011 Acerra, Italy
- Davor Milicic
- Department of Cardiology, University Hospital Centre, University of Zagreb, 10000 Zagreb, Croatia
- Periklis Davlouros
- Invasive Cardiology and Congenital Heart Disease, Patras University Hospital, 26221 Patras, Greece
- Nikola Bakraceski
- Center for Cardiovascular Diseases, 6000 Ohrid, North Macedonia
- Filippo Zilio
- Division of Cardiology, Ospedale Santa Chiara di Trento, 38014 Trento, Italy
- Luca Donazzan
- Division of Cardiology, Ospedale “S. Maurizio” Bolzano, 39100 Bolzano, Italy
- Adriaan Kraaijeveld
- Division of Cardiology, 3584 Utrecht, The Netherlands
- Gennaro Galasso
- Division of Cardiology, Ospedale San Giovanni di Dio e Ruggi d’Aragona, 84070 Salerno, Italy
- Lux Arpad
- Maastricht University Medical Center, 6229 Maastricht, The Netherlands
- Lucia Marinucci
- Division of Cardiology, Azienda Ospedaliera “Ospedali Riuniti Marche Nord”, 61121 Pesaro, Italy
- Vincenzo Guiducci
- Division of Cardiology, AUSL-IRCCS Reggio Emilia, 42121 Reggio Emilia, Italy
- Maurizio Menichelli
- Division of Cardiology, Ospedale “F. Spaziani”, 03100 Frosinone, Italy
- Alessandra Scoccia
- Division of Cardiology, Ospedale “Sant’Anna”, 44121 Ferrara, Italy
- Aylin Hatice Yamac
- Department of Cardiology, Bezmialem Vakif University Hospital, 34093 Istanbul, Turkey
- Kadir Ugur Mert
- Division of Cardiology, Faculty of Medicine, Eskisehir Osmangazi University, 02640 Eskisehir, Turkey
- Xacobe Flores Rios
- Complexo Hospetaliero Universitario La Coruna, 15001 La Coruna, Spain
- Tomas Kovarnik
- University Hospital Prague, 12808 Prague, Czech Republic
- Michal Kidawa
- Central Hospital of Medical University of Lodz, 90-008 Lodz, Poland
- Josè Moreu
- Division of Cardiology, Complejo Hospitalario de Toledo, 45001 Toledo, Spain
- Vincent Flavien
- Division of Cardiology, Center Hospitalier Universitaire de Lille, 59000 Lille, France
- Enrico Fabris
- Azienda Ospedaliero—Universitaria Ospedali Riuniti, 34142 Trieste, Italy
- Iñigo Lozano Martínez-Luengas
- Division of Cardiology, Hospital Cabueñes, 33201 Gijon, Spain
- Marco Boccalatte
- Division of Cardiology, Ospedale Santa Maria delle Grazie, 80078 Pozzuoli, Italy
- Francisco Bosa Ojeda
- Division of Cardiology, Hospital Universitario de Canarias, 38001 Santa Cruz de Tenerife, Spain
- Carlos Arellano-Serrano
- Division of Cardiology, Hospital Puerta de Hierro Majadahonda, 28222 Majadahonda, Spain
- Gianluca Caiazzo
- Division of Cardiology, Ospedale “G Moscati”, 81031 Aversa, Italy
- Giuseppe Cirrincione
- Division of Cardiology, Ospedale Civico Arnas, 90100 Palermo, Italy
- Hsien-Li Kao
- Cardiology Division, Department of Internal Medicine, National Taiwan University Hospital, Tapei 8865600, Taiwan
- Juan Sanchis Forés
- Division of Cardiology, Hospital Clinico Universitario de Valencia, 46010 Valencia, Spain
- Luigi Vignali
- Interventional Cardiology Unit, Azienda Ospedaliera Sanitaria, 43121 Parma, Italy
- Helder Pereira
- Cardiology Department, Hospital Garcia de Orta, Pragal, 2805-267 Almada, Portugal
- Santiago Ordoñez
- Instituto Cardiovascular de Buenos Aires, Buenos Aires 1428, Argentina
- Alev Arat Özkan
- Cardiology Institute, Istanbul University, 34000 Instanbul, Turkey
- Bruno Scheller
- Division of Cardiology, Clinical and Experimental Interventional Cardiology, University of Saarland, 66123 Saarbrücken, Germany
- Heidi Lehtola
- Division of Cardiology, Oulu University Hospital, 90220 Oulu, Finland
- Rui Teles
- Division of Cardiology, Hospital de Santa Cruz, CHLO—Nova Medical School, CEDOC, 1000 Lisbon, Portugal
- Christos Mantis
- Division of Cardiology, Kontantopoulion Hospital, 10431 Athens, Greece
- Ylitalo Antti
- Division of Cardiology, Heart Centre Turku, 20521 Turku, Finland
- João António Brum Silveira
- Division of Cardiology, Hospital de Santo António, 4099-001 Porto, Portugal
- Cesar Rodrigo Zoni
- Department of Teaching and Research, Instituto de Cardiología de Corrientes “Juana F. Cabral”, Corrientes W3400CDS, Argentina
- Ivan Bessonov
- Tyumen Cardiology Research Center, Tomsk National Research Medical Center, Russian Academy of Science, 634000-634538 Tomsk, Russia
- Giuseppe Uccello
- Division of Cardiology, Ospedale “A. Manzoni”, 23900 Lecco, Italy
- George Kochiadakis
- Iraklion University Hospital, 70001 Crete, Greece
- Dimitrios Alexopulos
- Division of Cardiology, Attikon University Hospital, 10431 Athens, Greece
- Carlos E. Uribe
- Division of Cardiology, Universidad UPB, Universidad CES, Medellín 050001, Colombia
- John Kanakakis
- Division of Cardiology, Alexandra Hospital, 10431 Athens, Greece
- Benjamin Faurie
- Division of Cardiology, Groupe Hospitalier Mutualiste de Grenoble, 38000 Grenoble, France
- Gabriele Gabrielli
- Interventional Cardiology Unit, Azienda Ospedaliero Universitaria“Ospedali Riuniti”, 60100 Ancona, Italy
- Alejandro Gutierrez Barrios
- Division of Cardiology, Hospital Puerta del Mar, 11001 Cadiz, Spain
- Juan Pablo Bachini
- Instituto de Cardiologia Integral, Montevideo 11700, Uruguay
- Alex Rocha
- Department of Cardiology and Cardiovascular Interventions, Instituto Nacional de Cirugía Cardíaca, Montevideo 11700, Uruguay
- Frankie C. C. Tam
- Department of Cardiology, Queen Mary Hospital, University of Hong Kong, Hong Kong
- Alfredo Rodriguez
- Division of Cardiology, Otamendi Hospital, Buenos Aires 1001, Argentina
- Antonia Anna Lukito
- Cardiovascular Department Pelita Harapan University, Heart Center Siloam Lippo Village Hospital, Tangerang, Banten 15810, Indonesia
- Veauthyelau Saint-Joy
- Center Hospitalier d’Antibes Juan Les Pins, 06600 Antibes, France
- Gustavo Pessah
- Division of Cardiology, Hospiatl Cordoba, Cordoba 5000, Argentina
- Andrea Tuccillo
- Division of Cardiology, Ospedale del Mare, 00156 Napoli, Italy
- Alfonso Ielasi
- Division of Cardiology, Nuovo Galeazzi-Sant’Ambrogio Hospital, 20161 Milan, Italy
- Giuliana Cortese
- Department of Statistical Sciences, University of Padova, 35121 Padova, Italy
- Guido Parodi
- Azienda Ospedaliera Lavagna, 16033 Lavagna, Italy
- Mohamed Abed Bouraghda
- Division of Cardiology, Blida University Hospital, Blida 09000, Algeria
- Marcia Moura
- Instituto de Cardiologia do Rio Grande do Sul, Porto Alegre 90040-371, Brazil
- Elvin Kedhi
- Division of Cardiology, Hopital Erasmus, Universitè Libre de Bruxelles, 1070 Brussels, Belgium
- Pablo Lamelas
- Instituto Cardiovascular de Buenos Aires, Buenos Aires 1428, Argentina
- Harry Suryapranata
- Division of Cardiology, Radboud University Medical Center, 6525 Nijmegen, The Netherlands
- Matteo Nardin
- Department of Internal Medicine, Ospedale Riuniti, 25121 Brescia, Italy
- Monica Verdoia
- Division of Cardiology, Ospedale degli Infermi, ASL, 13900 Biella, Italy
- DOI
- https://doi.org/10.3390/jcm12030896
- Journal volume & issue
-
Vol. 12,
no. 3
p. 896
Abstract
Background. Several reports have demonstrated the impact of the COVID-19 pandemic on the management and outcome of patients with ST-segment elevation myocardial infarction (STEMI). The aim of the current analysis is to investigate the potential gender difference in the effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI patients within the ISACS-STEMI COVID-19 Registry. Methods. This retrospective multicenter registry was performed in high-volume primary percutaneous coronary intervention (PPCI) centers on four continents and included STEMI patients undergoing PPCIs in March–June 2019 and 2020. Patients were divided according to gender. The main outcomes were the incidence and timing of the PPCI, (ischemia time ≥ 12 h and door-to-balloon ≥ 30 min) and in-hospital or 30-day mortality. Results. We included 16683 STEMI patients undergoing PPCIs in 109 centers. In 2020 during the pandemic, there was a significant reduction in PPCIs compared to 2019 (IRR 0.843 (95% CI: 0.825–0.861, p p p = 0.12). Conclusions. The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures similarly observed in both genders. Furthermore, we observed significantly increased in-hospital and 30-day mortality rates during the pandemic only among females. Trial registration number: NCT 04412655.
Keywords