Infection and Drug Resistance (Aug 2022)

Evaluation of Prevalence of Side-Effects Associated with Booster Dose of mRNA-Based COVID-19 Vaccine Among Healthcare Workers in Eastern Province, Saudi Arabia: A Descriptive Cross-Sectional Study

  • Ali MD,
  • Almadan LZ,
  • Alghamdi RA,
  • Alghamdi AS,
  • Almarhoon SA,
  • Hassan YAM,
  • Ahmad A,
  • Ghosn SA,
  • Banu N,
  • Eltrafi Z

Journal volume & issue
Vol. Volume 15
pp. 4335 – 4346

Abstract

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Mohammad Daud Ali, Leena Zakariya Almadan, Ruba Ahmed Alghamdi, Alanood Saleh Alghamdi, Sarah Ali Almarhoon, Yousif AM Hassan, Ayaz Ahmad, Sherihan Ahmad Ghosn, Nuzhat Banu, Zainab Eltrafi Department of Pharmacy, Mohammed Al-Mana College for Medical Sciences, Dammam, 34222, Saudi ArabiaCorrespondence: Mohammad Daud Ali, Department of Pharmacy, Mohammed Al-Mana College for Medical Sciences, Abdulrazaq Bin Hammam Street, Al Safa, Dammam, 34222, Saudi Arabia, Email [email protected]: The purpose of this study was to examine the mild and moderate side‐effects experienced by the healthcare workers (HCWs) in the Eastern Province of Saudi Arabia after receiving the booster dose of the Pfizer-BioNTech/BNT162b2 COVID‐19 vaccine.Methods: We directed a descriptive cross-sectional study among adults living in the Eastern Province of Saudi Arabia. A survey link was distributed through WhatsApp, SMS, or e-mail to HCWs. Participants’ general and demographic information were also collected, as well as information about any local and systemic side‐effects reported following vaccination.Results: The results of this study showed that 81.84% (401/490) of the HCWs who contributed to this study reported the minimum COVID‐19 post‐vaccination side‐effect. Body pain (89%) and pain at the site of injection (88.73%) were the most frequent frequently reported side‐effects, followed by headache (28.68%), joint or bone pain (27.18%), muscle pain (26.43%), nausea or vomiting (21.2%), fever (18.95%), skin rashes (10.22%). History of chronic diseases had a 0.44‐fold increased risk of side-effects compared to no history of chronic diseases HCWs (adjusted odds ratio (aOR) = 0.44; 95% CI = 0.224, 0.880), and significant association of occupation with side-effects was also 1.61-fold increased risk compared to nonmedical ((aOR) = 1.61; 95% CI = 1.037, 2.513).Conclusion: According to this study, the Pfizer-BioNTech/BNT162b2 COVID-19 vaccine was safe when given to Saudi Arabian HCWs. All reported side‐effects were mild to moderate. The outcomes indicated that most participants had body pain and pain at the site of injection and fatigue is among the least reported side-effect post-booster dose. Healthcare was highly connected with more reporting of side‐effects.Keywords: COVID‐19, vaccine, side‐effects, healthcare workers, Eastern Province, Saudi Arabia

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