Alveolar cell fate selection and lifelong maintenance of AT2 cells by FGF signaling

Douglas G. Brownfield; Alex Diaz de Arce; Elisa Ghelfi; Astrid Gillich; Tushar J. Desai; Mark A. Krasnow

doi:10.1038/s41467-022-34059-1

Nature Communications (Nov 2022)

Alveolar cell fate selection and lifelong maintenance of AT2 cells by FGF signaling

Douglas G. Brownfield,
Alex Diaz de Arce,
Elisa Ghelfi,
Astrid Gillich,
Tushar J. Desai,
Mark A. Krasnow

Affiliations

Douglas G. Brownfield: Department of Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine
Alex Diaz de Arce: Department of Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine
Elisa Ghelfi: Molecular and Integrative Physiological Sciences Program, Harvard T.H. Chan School of Public Health
Astrid Gillich: Department of Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine
Tushar J. Desai: Department of Internal Medicine and Stem Cell Institute, Stanford University School of Medicine
Mark A. Krasnow: Department of Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine

DOI: https://doi.org/10.1038/s41467-022-34059-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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Here the authors show that FGF signaling initiates alveolus development in mouse lung by inducing AT2 fate and a secondary signal for AT1 fate, and continuously maintains AT2 cells throughout life. FGF inhibition triggers immediate AT2 apoptosis and compensatory regeneration.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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