Nature Communications (Nov 2021)

Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren

  • Heng Liu,
  • Dapeng Sun,
  • Alexander Myasnikov,
  • Marjorie Damian,
  • Jean-Louis Baneres,
  • Ji Sun,
  • Cheng Zhang

DOI
https://doi.org/10.1038/s41467-021-26735-5
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 8

Abstract

Read online

Ghrelin is a central orexigenic peptide hormone in human energy homeostasis that is also known as ‘hunger hormone’ and signals through its GPCR, GHSR. Here, the authors present the cryo-EM structures of the human GHSR-Gi signaling complex with bound ghrelin and the synthetic non-peptide agonist ibutamoren that are of interest for drug design.