Lipid profiles in chronic spontaneous urticaria

Abstract

AbstractBackground: Chronic urticaria is referred as recurrent, pruritic, erythematous, and edematous mucocutaneous lesions on most days of week, and persists for six weeks or more. There is a hypothesis about the level of blood lipid profiles in chronic urticaria, based on which, high levels of serum lipids may have a contributing role in the development or exacerbation of hives attacks.Objectives: The present study investigated the association between chronic urticaria and blood lipid profiles.Method: Fifty patients with chronic urticaria and fifty healthy people were included in this case-control study. In chronic urticaria patients, severity of urticaria was determined and compared between both genders and 4 age groups. we checked blood lipid profiles in both case and control groups for significant differences. the relationship between the severity of urticaria in chronic urticaria patients, and their different serum levels of HDL, LDL, triglycerides, and cholesterol was also investigated. Results: levels of triglyceride (p Value=0.039), total cholesterol (p Value=0.031), and LDL (pValue= 0.001) were significantly higher in chronic urticaria patients than in the control group. no correlation was found between the urticaria severity score (UAS7) and the ages and sex of the patients. urticaria severity showed no significant difference within each lipid profile parameter. Average values of lipid profiles of patients with chronic urticaria in different age and sexes showed that HDL has remarkably higher mean quantitation in women than men (p<0.002). Conclusion: Our study found a correlation between chronic urticaria with hyperlipidemia. According to this investigation, we can advise that patients with chronic urticaria should be evaluated for hyperlipidemia.

Keywords

• hyperlipidemia, chronic urticaria, serum lipid profile