ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion

Wei-Guang Li; Ming-Gang Liu; Shining Deng; Yan-Mei Liu; Lin Shang; Jing Ding; Tsan-Ting Hsu; Qin Jiang; Ying Li; Fei Li; Michael Xi Zhu; Tian-Le Xu

doi:10.1038/ncomms13770

Nature Communications (Dec 2016)

ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion

Wei-Guang Li,
Ming-Gang Liu,
Shining Deng,
Yan-Mei Liu,
Lin Shang,
Jing Ding,
Tsan-Ting Hsu,
Qin Jiang,
Ying Li,
Fei Li,
Michael Xi Zhu,
Tian-Le Xu

Affiliations

Wei-Guang Li: Department of Anatomy, Discipline of Neuroscience, Histology and Embryology, and Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University School of Medicine
Ming-Gang Liu: Department of Anatomy, Discipline of Neuroscience, Histology and Embryology, and Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University School of Medicine
Shining Deng: Department of Developmental and Behavioral Pediatrics, Shanghai Institute of Pediatric Translational Medicine, Shanghai Children’s Medical Center, Ministry of Education–Shanghai Key Laboratory of Children’s Environmental Health, Shanghai Jiao Tong University School of Medicine
Yan-Mei Liu: Department of Anatomy, Discipline of Neuroscience, Histology and Embryology, and Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University School of Medicine
Lin Shang: Department of Developmental and Behavioral Pediatrics, Shanghai Institute of Pediatric Translational Medicine, Shanghai Children’s Medical Center, Ministry of Education–Shanghai Key Laboratory of Children’s Environmental Health, Shanghai Jiao Tong University School of Medicine
Jing Ding: Department of Developmental and Behavioral Pediatrics, Shanghai Institute of Pediatric Translational Medicine, Shanghai Children’s Medical Center, Ministry of Education–Shanghai Key Laboratory of Children’s Environmental Health, Shanghai Jiao Tong University School of Medicine
Tsan-Ting Hsu: Institute of Neuroscience, National Yang-Ming University
Qin Jiang: Department of Anatomy, Discipline of Neuroscience, Histology and Embryology, and Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University School of Medicine
Ying Li: Department of Anatomy, Discipline of Neuroscience, Histology and Embryology, and Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University School of Medicine
Fei Li: Department of Developmental and Behavioral Pediatrics, Shanghai Institute of Pediatric Translational Medicine, Shanghai Children’s Medical Center, Ministry of Education–Shanghai Key Laboratory of Children’s Environmental Health, Shanghai Jiao Tong University School of Medicine
Michael Xi Zhu: Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston
Tian-Le Xu: Department of Anatomy, Discipline of Neuroscience, Histology and Embryology, and Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University School of Medicine

DOI: https://doi.org/10.1038/ncomms13770
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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The acid-sensing ion channel, ASIC1a, is known to play a role in synaptic transmission and plasticity. Here, the authors demonstrate a role for ASIC1a in regulating plasticity in the insular cortex and find that extinction of conditioned taste aversion memory is disrupted in the ASIC1a knockout mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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