Albumin and Hyaluronic Acid-Coated Superparamagnetic Iron Oxide Nanoparticles Loaded with Paclitaxel for Biomedical Applications

Elena Vismara; Chiara Bongio; Alessia Coletti; Ravit Edelman; Andrea Serafini; Michele Mauri; Roberto Simonutti; Sabrina Bertini; Elena Urso; Yehuda G. Assaraf; Yoav D. Livney

doi:10.3390/molecules22071030

Molecules (Jun 2017)

Albumin and Hyaluronic Acid-Coated Superparamagnetic Iron Oxide Nanoparticles Loaded with Paclitaxel for Biomedical Applications

Elena Vismara,
Chiara Bongio,
Alessia Coletti,
Ravit Edelman,
Andrea Serafini,
Michele Mauri,
Roberto Simonutti,
Sabrina Bertini,
Elena Urso,
Yehuda G. Assaraf,
Yoav D. Livney

Affiliations

Elena Vismara: Department of Chemistry, Materials and Chemical Engineering “G. Natta”, Politecnico di Milano, 20131 Milano, Italy
Chiara Bongio: Department of Chemistry, Materials and Chemical Engineering “G. Natta”, Politecnico di Milano, 20131 Milano, Italy
Alessia Coletti: Department of Chemistry, Materials and Chemical Engineering “G. Natta”, Politecnico di Milano, 20131 Milano, Italy
Ravit Edelman: Biotechnology and Food Engineering Department, Technion-Israel Institute of Technology, Haifa 3200000, Israel
Andrea Serafini: Department of Chemistry, Materials and Chemical Engineering “G. Natta”, Politecnico di Milano, 20131 Milano, Italy
Michele Mauri: Department of Materials Science, University of Milan Bicocca, 20125 Milano, Italy
Roberto Simonutti: Biotechnology and Food Engineering Department, Technion-Israel Institute of Technology, Haifa 3200000, Israel
Sabrina Bertini: Istituto scientifico di chimica e biochimica “G. Ronzoni”, 20133 Milano, Italy
Elena Urso: Istituto scientifico di chimica e biochimica “G. Ronzoni”, 20133 Milano, Italy
Yehuda G. Assaraf: Biology Department, Technion-Israel Institute of Technology, Haifa 3200000, Israel
Yoav D. Livney: Biotechnology and Food Engineering Department, Technion-Israel Institute of Technology, Haifa 3200000, Israel

DOI: https://doi.org/10.3390/molecules22071030
Journal volume & issue: Vol. 22, no. 7
p. 1030

Abstract

Read online

Super paramagnetic iron oxide nanoparticles (SPION) were augmented by both hyaluronic acid (HA) and bovine serum albumin (BSA), each covalently conjugated to dopamine (DA) enabling their anchoring to the SPION. HA and BSA were found to simultaneously serve as stabilizing polymers of Fe3O4·DA-BSA/HA in water. Fe3O4·DA-BSA/HA efficiently entrapped and released the hydrophobic cytotoxic drug paclitaxel (PTX). The relative amount of HA and BSA modulates not only the total solubility but also the paramagnetic relaxation properties of the preparation. The entrapping of PTX did not influence the paramagnetic relaxation properties of Fe3O4·DA-BSA. Thus, by tuning the surface structure and loading, we can tune the theranostic properties of the system.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

About the journal

Abstract

Keywords