Clinicopathological and Molecular Features of Colorectal Cancer Patients With Mucinous and Non-Mucinous Adenocarcinoma

Yuan-Tzu Lan; Yuan-Tzu Lan; Shih-Ching Chang; Shih-Ching Chang; Pei-Ching Lin; Pei-Ching Lin; Chun-Chi Lin; Chun-Chi Lin; Hung-Hsin Lin; Hung-Hsin Lin; Shen-Chieh Huang; Shen-Chieh Huang; Chien-Hsing Lin; Wen-Yi Liang; Wei-Shone Chen; Wei-Shone Chen; Jeng-Kai Jiang; Jeng-Kai Jiang; Jen-Kou Lin; Jen-Kou Lin; Shung-Haur Yang; Shung-Haur Yang; Shung-Haur Yang

doi:10.3389/fonc.2021.620146

Frontiers in Oncology (Mar 2021)

Clinicopathological and Molecular Features of Colorectal Cancer Patients With Mucinous and Non-Mucinous Adenocarcinoma

Yuan-Tzu Lan,
Yuan-Tzu Lan,
Shih-Ching Chang,
Shih-Ching Chang,
Pei-Ching Lin,
Pei-Ching Lin,
Chun-Chi Lin,
Chun-Chi Lin,
Hung-Hsin Lin,
Hung-Hsin Lin,
Shen-Chieh Huang,
Shen-Chieh Huang,
Chien-Hsing Lin,
Wen-Yi Liang,
Wei-Shone Chen,
Wei-Shone Chen,
Jeng-Kai Jiang,
Jeng-Kai Jiang,
Jen-Kou Lin,
Jen-Kou Lin,
Shung-Haur Yang,
Shung-Haur Yang,
Shung-Haur Yang

Affiliations

Yuan-Tzu Lan: Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
Yuan-Tzu Lan: Department of Surgery, Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
Shih-Ching Chang: Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
Shih-Ching Chang: Department of Surgery, Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
Pei-Ching Lin: Department of Clinical Pathology, Taipei City Hospital, Taipei, Taiwan
Pei-Ching Lin: Department of Health and Welfare, University of Taipei, Taipei, Taiwan
Chun-Chi Lin: Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
Chun-Chi Lin: Department of Surgery, Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
Hung-Hsin Lin: Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
Hung-Hsin Lin: Department of Surgery, Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
Shen-Chieh Huang: Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
Shen-Chieh Huang: Department of Surgery, Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
Chien-Hsing Lin: Division of Genomic Medicine, National Health Research Institutes, Zhunan, Taiwan
Wen-Yi Liang: Department of Pathology, Taipei Veterans General Hospital, Taipei, Taiwan
Wei-Shone Chen: Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
Wei-Shone Chen: Department of Surgery, Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
Jeng-Kai Jiang: Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
Jeng-Kai Jiang: Department of Surgery, Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
Jen-Kou Lin: Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
Jen-Kou Lin: Department of Surgery, Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
Shung-Haur Yang: Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
Shung-Haur Yang: Department of Surgery, Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
Shung-Haur Yang: Department of Surgery, National Yang Ming Chiao Tung University Hospital, Yilan, Taiwan

DOI: https://doi.org/10.3389/fonc.2021.620146
Journal volume & issue: Vol. 11

Abstract

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BackgroundThe prognosis of mucinous adenocarcinoma (MAC) and non-mucinous adenocarcinoma (NMAC) in colorectal cancer (CRC) is controversial, and the molecular differences between them are unclear.MethodsBetween 2000 and 2010, a total of 1,483 CRC patients were included. Among them, 73 patients (4.9%) were diagnosed with MAC. The clinicopathological features and genetic alterations were compared between MAC and NMAC.ResultsAfter propensity score matching to balance age and sex between MAC and NMAC patients, 292 CRC patients (73 MAC and 219 NMAC) were enrolled in the analysis at a 1:3 ratio. In right-sided colon cancer, patients with MAC were more likely to have Borrmann types 3 and 4 tumors, poor differentiation, and advanced T category and tumor, node, metastasis (TNM) stage, chemotherapy, and a similar 5-year overall survival (OS) rate compared with patients with NMAC. In left-sided colon cancer and rectal cancer, patients with MAC were more likely to have Borrmann types 3 and 4 tumors, poor differentiation, lymphovascular invasion, advanced T and N categories and TNM stages, chemotherapy, and a worse 5-year OS rate than patients with NMAC. Regarding genetic alterations, for NMAC, right-sided colon cancer had more BRAF mutations than left-sided colon cancer and rectal cancer. For MAC, right-sided colon cancer was associated with more microsatellite instability-high tumors and more AKT1 mutations than left-sided colon cancer and rectal cancer.ConclusionThe genetic alterations are distinct between MAC and NMAC in CRC. Tumor location may have an impact on genetic alterations and patient prognosis in MAC and NMAC.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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