Association between melanocytic neoplasms and seborrheic keratosis: more than a coincidental collision?

Abstract

Clinical observations and an expanding knowledge of cell-to-cell communication have led us to speculate that the finding of a melanocytic nevus in conjunction with a seborrheic keratosis is more than a coincidental collision of two lesions. Here we present five cases demonstrating dermoscopic features of both melanocytic lesions and seborrheic keratoses with corresponding histology. Four cases demonstrate dermoscopic features of a melanocytic nevus and seborrheic keratosis, and the final case a melanoma arising in association with a seborrheic keratosis.

Keywords

• seborrheic keratosis
• melanocytes nevus
• cell-signalling
• melanocytes
• keratinocytes