iScience (Nov 2024)
Transcriptional profile of Mycobacterium tuberculosis infection in people living with HIV
- Burcu Tepekule,
- Lisa Jörimann,
- Corinne D. Schenkel,
- Lennart Opitz,
- Jasmin Tschumi,
- Rebekka Wolfensberger,
- Kathrin Neumann,
- Katharina Kusejko,
- Marius Zeeb,
- Lucas Boeck,
- Marisa Kälin,
- Julia Notter,
- Hansjakob Furrer,
- Matthias Hoffmann,
- Hans H. Hirsch,
- Alexandra Calmy,
- Matthias Cavassini,
- Niklaus D. Labhardt,
- Enos Bernasconi,
- Gabriela Oesch,
- Karin J. Metzner,
- Dominique L. Braun,
- Huldrych F. Günthard,
- Roger D. Kouyos,
- Fergal Duffy,
- Johannes Nemeth
Affiliations
- Burcu Tepekule
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland; Institute of Medical Virology, University of Zurich, Zurich, Switzerland; Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA
- Lisa Jörimann
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland; Institute of Medical Virology, University of Zurich, Zurich, Switzerland
- Corinne D. Schenkel
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland; Institute of Medical Virology, University of Zurich, Zurich, Switzerland
- Lennart Opitz
- Functional Genomics Center Zurich, Swiss Federal Institute of Technology and University of Zurich, Zurich, Switzerland
- Jasmin Tschumi
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland; Institute of Medical Virology, University of Zurich, Zurich, Switzerland
- Rebekka Wolfensberger
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland
- Kathrin Neumann
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland; Institute of Medical Virology, University of Zurich, Zurich, Switzerland
- Katharina Kusejko
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland
- Marius Zeeb
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland; Institute of Medical Virology, University of Zurich, Zurich, Switzerland
- Lucas Boeck
- Department of Biomedicine, University of Basel, Basel, Switzerland
- Marisa Kälin
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland
- Julia Notter
- Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St Gallen, St. Gallen, Switzerland
- Hansjakob Furrer
- Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
- Matthias Hoffmann
- Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital Olten, Olten, Switzerland
- Hans H. Hirsch
- Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Basel, Switzerland; Clinical Virology, Laboratory Medicine, University Hospital Basel, Basel, Switzerland; Department Biomedicine, Transplantation and Clinical Virology, University of Basel, Basel, Switzerland
- Alexandra Calmy
- Division of Infectious Diseases, University Hospital Geneva, University of Geneva, Geneva, Switzerland
- Matthias Cavassini
- Division of Infectious Diseases, University Hospital Lausanne, University of Lausanne, Lausanne, Switzerland
- Niklaus D. Labhardt
- Division Clinical Epidemiology, Department of Clinical Research, University Hospital Basel, Basel, Switzerland; University of Basel, Basel, Switzerland
- Enos Bernasconi
- Division of Infectious Diseases, University Hospital Geneva, University of Geneva, Geneva, Switzerland; Division of Infectious Diseases, Ente Ospedaliero Cantonale, Lugano, Switzerland; University of Geneva and University of Southern Switzerland, Lugano, Switzerland
- Gabriela Oesch
- Department of Child Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
- Karin J. Metzner
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland; Institute of Medical Virology, University of Zurich, Zurich, Switzerland
- Dominique L. Braun
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland; Institute of Medical Virology, University of Zurich, Zurich, Switzerland
- Huldrych F. Günthard
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland; Institute of Medical Virology, University of Zurich, Zurich, Switzerland
- Roger D. Kouyos
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland; Institute of Medical Virology, University of Zurich, Zurich, Switzerland
- Fergal Duffy
- Seattle Children’s Research Institute, Seattle, WA, USA
- Johannes Nemeth
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland; Corresponding author
- Journal volume & issue
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Vol. 27,
no. 11
p. 111228
Abstract
Summary: In people with HIV-1 (PWH), Mycobacterium tuberculosis (MTB) infection poses a significant threat. While active tuberculosis (TB) accelerates immunodeficiency, the interaction between MTB and HIV-1 during asymptomatic phases remains unclear. Analysis of peripheral blood mononuclear cells (PBMC) transcriptomic profiles in PWH, with and without controlled viral loads, revealed distinct clustering in MTB-infected individuals. Functional annotation identified alterations in IL-6, TNF, and KRAS pathways. Notably, MTB-related genes displayed an inverse correlation with HIV-1 viremia, at both individual and signature score levels. These findings suggest that MTB infection in PWH induces a shift in immune system activation, inversely related to HIV-1 viral load. These results may explain the observed enhanced antiretroviral control in MTB-infected PWH. This study highlights the complex interplay between MTB and HIV-1, emphasizing the importance of understanding their interaction for managing co-infections in this population.
