P8.13 CORONARY IMPLANTATION OF SIROLIMUS-ELUTING STENT IMPAIRS THE PERIPHERAL VASCULAR COMPLIANCE IN PATIENT WITH CORONARY ARTERY DISEASE

Abstract

Introduction: To the best of our knowledge, any studies evaluated potential influence on peripheral arterial stiffness, measured by pulse wave velocity (PWV), of percoutaneous coronary intervention (PCI) and stenting. Methods: 150 patients were enrolled and underwent coronary angiography. In 68 patients was performed coronary stenting (PCI group). PWV was invasively obtained before and after coronary stenting. Results: Coronary stenting produced a significant augment of PWV (from 4.59 to 5.82m/s, P=0.000). In contrast, the sub-population which performed angiography without PCI (noPCI group), didn’t show any significant change in PWV. The analysis of PCI group demonstrated that only implantation of Sirolimus eluting stent (SES) caused a significant increase of PWV (from 4.62 to 6.15m/s, P=0.029). In a stepwise multiple regression model stent length, glycaemia and body mass index were significantly associated with increase of PWV, accounting for a total of 51.7% of the variation (P=0.009). In particular, stent length accounted for 39.6% of the variance in PWV augmentation; glycaemia and body mass index explained an additional 12.1% of its variability. In the same analysis performed in PCI group, stent length accounted for 65.3% of the variance (P=0.024) and other than glycaemia and body mass index, also implantation of SES explained an additional 18.5%. Conclusion: We have shown, for the first time, a significant association between SES implantation and an central stiffness worsening.