JAK and mTOR inhibitors prevent cytokine release while retaining T cell bispecific antibody in vivo efficacy

• Christian Klein,
• Marina Bacac,
• Pablo Umana,
• Martin Stern,
• Gabrielle Leclercq,
• Hélène Haegel,
• Anneliese Schneider,
• Anna Maria Giusti,
• Vesna Pulko,
• Johannes Sam,
• John Challier,
• Alex Odermatt,
• Luke Green,
• Alberto Toso,
• Tina Zimmermann,
• Nathalie Steinhoff,
• Anne Freimoser-Grundschober,
• Laurent Larivière

Affiliations

Christian Klein

Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland

Marina Bacac

Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland

Pablo Umana

Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland

Martin Stern

Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland

Gabrielle Leclercq

Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland

Hélène Haegel

Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland

Anneliese Schneider

Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland

Anna Maria Giusti

Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland

Vesna Pulko

Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland

Johannes Sam

Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland

John Challier

Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland

Alex Odermatt

Department of Pharmaceutical Sciences, Division Molecular and Systems Toxicology, University of Basel, Basel, Switzerland

Luke Green

Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland

Alberto Toso

Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland

Tina Zimmermann

Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland

Nathalie Steinhoff

Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland

Anne Freimoser-Grundschober

Roche Pharmaceutical Research and Early Development, Roche Innovation Center Zurich, Schlieren, Switzerland

Laurent Larivière

Roche Pharmaceutical Research and Early Development, Roche Innovation Center Munich, Penzberg, Germany