COULD ANTI-SYNTHETASE SYNDROME BE A GOOD PREDICTOR FACTOR FOR INTERSTITIAL LUNG DISEASE?

Abstract

Anti-synthetase syndrome (SAS) is an autoimmune inflammatory myopathy, whose immune profile is dominated by anti-RNA synthetase antibodies (ARS), with a specific clinical phenotype. The major diagnostic criteria of SAS include the triad of myositis, arthritis and interstitial lung disease (ILD), on the background of positive anti-ARS antibodies. ILD in SAS, has a good evolution compared to the one in PM/DM, due to protective presence of anti Jo-1 antibodies.

Keywords

• anti-synthetase syndrome
• anti-rna
• polymyositis
• dermatomyositis