Copper-catalyzed dehydrogenative γ-C(sp3)-H amination of saturated ketones for synthesis of polysubstituted anilines

Rong Hu; Fa-Jie Chen; Xiaofeng Zhang; Min Zhang; Weiping Su

doi:10.1038/s41467-019-11624-9

Nature Communications (Aug 2019)

Copper-catalyzed dehydrogenative γ-C(sp3)-H amination of saturated ketones for synthesis of polysubstituted anilines

Rong Hu,
Fa-Jie Chen,
Xiaofeng Zhang,
Min Zhang,
Weiping Su

Affiliations

Rong Hu: School of Physical Science and Technology, ShanghaiTech University
Fa-Jie Chen: State Key Laboratory of Structural Chemistry, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences
Xiaofeng Zhang: State Key Laboratory of Structural Chemistry, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences
Min Zhang: State Key Laboratory of Structural Chemistry, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences
Weiping Su: School of Physical Science and Technology, ShanghaiTech University

DOI: https://doi.org/10.1038/s41467-019-11624-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

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Functionalising ketones at the γ-position is not a trivial synthetic task. Here, the authors developed a copper-catalyzed dehydrogenative γ-amination of saturated ketones, which can then participate in a 3-component coupling reaction to construct polysubstituted anilines.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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