Nature Communications (Oct 2018)
Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism
- James Peek,
- Mirjana Lilic,
- Daniel Montiel,
- Aleksandr Milshteyn,
- Ian Woodworth,
- John B. Biggins,
- Melinda A. Ternei,
- Paula Y. Calle,
- Michael Danziger,
- Thulasi Warrier,
- Kohta Saito,
- Nathaniel Braffman,
- Allison Fay,
- Michael S. Glickman,
- Seth A. Darst,
- Elizabeth A. Campbell,
- Sean F. Brady
Affiliations
- James Peek
- Laboratory of Genetically Encoded Small Molecules, The Rockefeller University
- Mirjana Lilic
- Laboratory of Molecular Biophysics, The Rockefeller University
- Daniel Montiel
- Laboratory of Genetically Encoded Small Molecules, The Rockefeller University
- Aleksandr Milshteyn
- Laboratory of Genetically Encoded Small Molecules, The Rockefeller University
- Ian Woodworth
- Laboratory of Genetically Encoded Small Molecules, The Rockefeller University
- John B. Biggins
- Laboratory of Genetically Encoded Small Molecules, The Rockefeller University
- Melinda A. Ternei
- Laboratory of Genetically Encoded Small Molecules, The Rockefeller University
- Paula Y. Calle
- Laboratory of Genetically Encoded Small Molecules, The Rockefeller University
- Michael Danziger
- Laboratory of Genetically Encoded Small Molecules, The Rockefeller University
- Thulasi Warrier
- Department of Microbiology and Immunology, Weill Cornell Medicine
- Kohta Saito
- Department of Microbiology and Immunology, Weill Cornell Medicine
- Nathaniel Braffman
- Laboratory of Molecular Biophysics, The Rockefeller University
- Allison Fay
- Immunology Program, Sloan-Kettering Institute
- Michael S. Glickman
- Immunology Program, Sloan-Kettering Institute
- Seth A. Darst
- Laboratory of Molecular Biophysics, The Rockefeller University
- Elizabeth A. Campbell
- Laboratory of Molecular Biophysics, The Rockefeller University
- Sean F. Brady
- Laboratory of Genetically Encoded Small Molecules, The Rockefeller University
- DOI
- https://doi.org/10.1038/s41467-018-06587-2
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Resistance to rifamycin antibiotics, which target bacterial RNA polymerases, is a growing problem. Here, the authors identify gene clusters from soil metagenomes encoding production of rifamycin analogues that are active against rifampicin-resistant bacteria through a distinct mechanism.
