Revista Cubana de Hematología, Inmunología y Hemoterapia (Apr 2002)

Evaluación de la función opsono fagocítica de los neutrófilos en pacientes infectados por el VIH Evaluation of the opsonophagocytic function of neutrophils in HIV-infected patients

  • Randelys Molina Castro,
  • Alejandro Álvarez García,
  • Liliana Pérez Toledo,
  • Lizet Sánchez Valdés,
  • Yondel Torranzo Soto,
  • Caridad Luzardo Suárez

Journal volume & issue
Vol. 18, no. 1
p. 0

Abstract

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La disfunción de los neutrófilos podría contribuir a la susceptibilidad a infecciones observada en los pacientes infectados por el virus de inmunodeficiencia humana (VIH). Se realizó un estudio de corte transversal para evaluar la opsono fagocitosis de los neutrófilos en estos pacientes, en el que participaron 104 individuo: 25 donantes de sangre (grupo control) y 79 VIH positivos (+). Estos últimos se dividieron en 3 grupos según su conteo global de linfocitos T CD4 + (CGLCD4): grupo 1 compuesto por 24 individuos con CGLCD4³500 células/mm3; grupo 2 por 26 pacientes con CGLCD4 de 200 a 499 células/mm3; y grupo 3 por 29 casos con CGLCD4 The dysfunction of neutrophils could contribute to susceptibility to infections observed in HIV-infected patients. A cross-sectional study was conducted to evaluate the opsonophagocytosis of neutrophils in these patients. One hundred and four individuals participated in it: 25 blood donors (the control group) and 79 HIV-positive patients who were distributed into 3 groups according to the global count of CD4 lymphocytes (GLCCD4): Group 1 composed of 24 individuals with GLCCD4³ 500 cell/mm3, Group 2 with 26 patients with GLCCD4 of 200-499 cell/mm3 and Group 3 composed by 29 patients with GLCCD4 < 200 cell/mm3 . Absolute values of leukocytes and granulocytes and relative values of lymphocytes were determined, CD4+ lymphocyte T subset was quantified and the opsonophagocytic index was estimated. A significant reduction (p< 0,05) in absolute count of leukocytes and granulocytes and in the opsonophagocytic function was found in HIV-infected patients compared with the control group. There was a non-linear direct relation of the absolute count of CD4+ T lymphocytes with global count of leukocytes and granulocytes and the opsonophagocytic function

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