Complete microtubule–kinetochore occupancy favours the segregation of merotelic attachments

Damian Dudka; Anna Noatynska; Chris A. Smith; Nicolas Liaudet; Andrew D. McAinsh; Patrick Meraldi

doi:10.1038/s41467-018-04427-x

Nature Communications (May 2018)

Complete microtubule–kinetochore occupancy favours the segregation of merotelic attachments

Damian Dudka,
Anna Noatynska,
Chris A. Smith,
Nicolas Liaudet,
Andrew D. McAinsh,
Patrick Meraldi

Affiliations

Damian Dudka: Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva
Anna Noatynska: Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva
Chris A. Smith: Centre for Mechanochemical Cell Biology & Division of Biomedical Sciences, Warwick Medical School, University of Warwick
Nicolas Liaudet: Bioimaging Facility, Faculty of Medicine, University of Geneva
Andrew D. McAinsh: Centre for Mechanochemical Cell Biology & Division of Biomedical Sciences, Warwick Medical School, University of Warwick
Patrick Meraldi: Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva

DOI: https://doi.org/10.1038/s41467-018-04427-x
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 16

Abstract

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Single microtubules (MTs) can move chromosomes, but it is unclear why kinetochores bind up to 20 MTs. Here, the authors decrease the number of kinetochore MTs with BAL27862 and see lagging chromosomes, suggesting that numerous kinetochore MTs provide force ensuring robust chromosomal segregation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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