Frontiers in Nutrition (Sep 2022)

MYBIOTA: A birth cohort on maternal and infant microbiota and its impact on infant health in Malaysia

  • Shiang Yen Eow,
  • Wan Ying Gan,
  • Tiemin Jiang,
  • Tiemin Jiang,
  • Su Peng Loh,
  • Ling Jun Lee,
  • Yit Siew Chin,
  • Yit Siew Chin,
  • Leslie Thian Lung Than,
  • Kang Nien How,
  • Pui Ling Thong,
  • Yanpin Liu,
  • Yanpin Liu,
  • Junying Zhao,
  • Junying Zhao,
  • Lijun Chen,
  • Lijun Chen

DOI
https://doi.org/10.3389/fnut.2022.994607
Journal volume & issue
Vol. 9

Abstract

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BackgroundThe microbiota plays a key role in early immunity maturation that affects infant health and is associated with the development of non-communicable diseases and allergies in later life.ObjectiveThe MYBIOTA is a prospective mother-infant cohort study in Malaysia aiming to determine the association between gut microbiota with infant health (temperament, gastrointestinal disorders, eczema, asthma, and developmental delays) in Selangor, Malaysia.MethodsPregnant mothers will be enrolled in their first trimester of pregnancy, and follow-ups will be done for infants during their first year of life. Maternal-infant biological samples (blood, feces, saliva, urine, and breast milk), anthropometric, dietary, and clinical information will be collected at different time points from early pregnancy to 12 months postpartum.DiscussionThis study could provide a better understanding of the colonization and development of the gut microbiome during early life and its impact on infant health.Clinical trial registrationhttps://clinicaltrials.gov/, identifier NCT04919265.

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